Search Results - franco+d%27alessio

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Prodrug for Immunological and Oncological Therapy

Unmet NeedApproximately 1.24 million hematological cancer cases occur each year, accounting for approximately 6% of all cancer cases (Bristol Myers Squibb). Currently, standard treatment strategies include chemotherapy, radiation therapy, and stem cell transplants. However, there exist several major drawbacks for each method. Stem cell transplants can...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, Franco D'alessio, Pavel Majer, Marcela Krecmerova, Srinivasan Yegnasubramanian

Keywords(s): Blood Cancer, Cancers, Disease Indication, Inflammatory Disorders, Respiratory Infections, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Small Molecules

Diagnostic and Treatment Target for Checkpoint Inhibitor Pneumonitis

Unmet Need Checkpoint inhibitor pneumonitis (CIP) can develop as a complication of cancer immunotherapy and is the leading cause of treatment-related death. CIP incidence will continue to rise as immunotherapy treatments become more widespread. However, there are no reliable biomarkers for CIP diagnosis or prognosis. Current approaches for CIP management...

Published: 5/10/2024 | Inventor(s): Karthik Suresh, Mohammad Ghanbar, Franco D'alessio

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets

Therapies to Accelerate Resolution of Acute Lung Inflammation

Acute respiratory distress syndrome (ARDS) is a devastating inflammatory lung disease for which there are no effective targeted therapies. In experimental models of acute lung inflammation and injury, regulatory T cells (Tregs) orchestrate a pro-repair program; Tregs themselves are highly dependent on epigenetic mechanisms such as DNA hypomethylation. ...

Published: 5/9/2024 | Inventor(s): Franco D'alessio, Landon King, Benjamin Singer, Neil Aggarwal

Keywords(s): Acute Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome (ARDS), Antagonists/Inhibitors, Chemotherapy, Disease Indication, Immunotherapy, Lung Disorders, Non-novel, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Repurposed Drugs