Search Results - therapeutic+substance+synthesis+method

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Prodrug for Immunological and Oncological Therapy

Unmet NeedApproximately 1.24 million hematological cancer cases occur each year, accounting for approximately 6% of all cancer cases (Bristol Myers Squibb). Currently, standard treatment strategies include chemotherapy, radiation therapy, and stem cell transplants. However, there exist several major drawbacks for each method. Stem cell transplants can...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, Franco D'alessio, Pavel Majer, Marcela Krecmerova, Srinivasan Yegnasubramanian

Keywords(s): Blood Cancer, Cancers, Disease Indication, Inflammatory Disorders, Respiratory Infections, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Small Molecules

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers

N-Acyloxysulfonamide and N-Hydroxy-N-acylsulfonamide Derivatives as Stabilized HNO Donors

Technology OverviewThe invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions...

Published: 5/9/2024 | Inventor(s): Art Sutton, Stephen Courtney, Vincent Kalish, Frederick Brookfield, Lisa Frost, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

Bis-Acylated Hydroxylamine Derivatives as Physiologically Useful HNO Donors

Technology OverviewThe invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing,...

Published: 5/9/2024 | Inventor(s): Frederick Brookfield, Vincent Kalish, Lisa Frost, Art Sutton, Stephen Courtney, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors

Technology OverviewThe disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions...

Published: 5/9/2024 | Inventor(s): Daryl Guthrie, John Toscano

Keywords(s): Cardiovascular Diseases, Disease Indication, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Controlled HNO Release through Intramolecular Cyclization-Elimination

#C12038Inventor(s): John Toscano, Art SuttonUnmet Need:An estimated 17.9 million people died from cardiovascular diseases in 2019, representing 32% of all global deaths (see WHO). Nitroglycerin has been used as a vasodilator to treat heart conditions for over 130 years. It wasn't until 2003 that scientists realized the beneficial effect was due...

Published: 5/9/2024 | Inventor(s): Art Sutton, John Toscano

Keywords(s): Cancers, Cardiovascular Diseases, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Polymer of Prodrug Methods for Sustained Release of Antivirals for Treatment or Prevention of HIV

Unmet Need:Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are amongst the most serious and challenging health problems in the world. There are nearly 37 million people worldwide living with HIV/AIDS and approximately 1 million AIDS-related deaths have occurred in 2017 alone - about 5,000 new infections per...

Published: 5/9/2024 | Inventor(s): Caren Freel Meyers, Steven Rannard, Andrew Owen, Kartik Temburnikar, Lauren Coco, Stephanie Henriquez, Faye Hern, Chung Liu, Anika Shakil, Megan Neary

Keywords(s): Disease Indication, HIV, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Rapid Automated Extraction of Mosquito Salivary Glands through Fluid Dynamics & Computer Vision

Unmet NeedMalaria is one of the world’s most common mosquito-borne illnesses, with an estimated 219 million cases and 435,000 deaths in 2017. An estimated $12 billion is lost every year in Africa due to malaria. Although vaccines have been developed to eradicate malaria, vaccine production is hindered by an inefficient process and high costs. Vaccine...

Published: 5/9/2024 | Inventor(s): Gregory Chirikjian, John Chirikjian, Brian Chirikjian, Russell Taylor, Joshua Davis

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities

Non-immunosuppressive FK506 analogs and use thereof

Unmet NeedChronic, nonhealing wounds are estimated to affect approximately 2% of the general population, and the cost of caring for these wounds exceeds $50 billion per year. These costs are expected to rise due to the increasing prevalence of diabetes and other diseases that hinder wound healing. Chronic infections increase morbidity and mortality...

Published: 5/9/2024 | Inventor(s): Jun Liu, Zhaoli Sun, Brandon Peiffer, Yuefan Wang, Le Qi, Zufeng Guo, Hanjing Peng, Ali Ahmadi

Keywords(s): Antagonists/Inhibitors, Combination, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type, Transplants

Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Small Molecules

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

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