Search Results - vincent+kalish

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N-Acyloxysulfonamide and N-Hydroxy-N-acylsulfonamide Derivatives as Stabilized HNO Donors

Technology OverviewThe invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions...

Published: 5/9/2024 | Inventor(s): Art Sutton, Stephen Courtney, Vincent Kalish, Frederick Brookfield, Lisa Frost, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

Bis-Acylated Hydroxylamine Derivatives as Physiologically Useful HNO Donors

Technology OverviewThe invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing,...

Published: 5/9/2024 | Inventor(s): Frederick Brookfield, Vincent Kalish, Lisa Frost, Art Sutton, Stephen Courtney, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Technology OverviewThe invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide...

Published: 5/9/2024 | Inventor(s): Lisa Frost, Vincent Kalish, Andrew Cohen, Frederick Brookfield, Stephen Courtney, John Toscano

Keywords(s): Cardiovascular Diseases, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Technology OverviewThe invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide...

Published: 5/9/2024 | Inventor(s): Andrew Cohen, Frederick Brookfield, Vincent Kalish, Stephen Courtney, Lisa Frost, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

N-hydroxylsulfonamide Derivatives as Nitroxyl Donors

#C13855Inventor(s): John Toscano, Vincent Kalish, Lisa Frost, Frederick Brookfield, Stephen CourtneyUnmet NeedAn estimated 17.9 million people died from cardiovascular diseases in 2019, representing 32% of all global deaths (see WHO). Nitroglycerin has been used as a vasodilator to treat heart conditions for over 130 years. It wasn't until 2003...

Published: 5/9/2024 | Inventor(s): John Toscano, Vincent Kalish, Lisa Frost, Frederick Brookfield, Stephen Courtney

Keywords(s): Cardiovascular Diseases, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Pyrazolone Derivatives as Nitroxyl Donors

#C13496Inventor(s): John Toscano, Daryl Guthrie, Vince Kalish, Fredrick A. Brookfield, Stephen M. Courtney, Lisa M. Frost, Carl L. NorthUnmet NeedAn estimated 17.9 million people died from cardiovascular diseases in 2019, representing 32% of all global deaths (see WHO). Nitroglycerin has been used as a vasodilator to treat heart conditions for over...

Published: 5/9/2024 | Inventor(s): John Toscano, Daryl Guthrie, Vincent Kalish, Frederick Brookfield, Stephen Courtney, Lisa Frost, Carl North

Keywords(s): Cardiovascular Diseases, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Johns Hopkins University PROTEIN-DB2 Database System

C04853: Johns Hopkins University PROTEIN-DB2 Database SystemNovelty: The current invention is a relational database for proteomic experiments.Value Proposition: Proteomic data collection follows complex workflow, ranging from gel electrophoresis to mass spectrometry to liquid chromatography or a combination thereof. In addition, amplification of low-abundance...

Published: 5/9/2024 | Inventor(s): Raimond Winslow, Stephen Granite, Chunguang Yang, Ali Ali, Donita Robinson

Keywords(s): Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases