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N-Acyloxysulfonamide and N-Hydroxy-N-acylsulfonamide Derivatives as Stabilized HNO Donors

Technology OverviewThe invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions...

Published: 5/9/2024 | Inventor(s): Art Sutton, Stephen Courtney, Vincent Kalish, Frederick Brookfield, Lisa Frost, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

Bis-Acylated Hydroxylamine Derivatives as Physiologically Useful HNO Donors

Technology OverviewThe invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing,...

Published: 5/9/2024 | Inventor(s): Frederick Brookfield, Vincent Kalish, Lisa Frost, Art Sutton, Stephen Courtney, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Technology OverviewThe invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide...

Published: 5/9/2024 | Inventor(s): Andrew Cohen, Frederick Brookfield, Vincent Kalish, Stephen Courtney, Lisa Frost, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

O‐substituted hydroxamic acids with pyrazolone leaving groups as novel physiologically useful HNO donors

#C14009Inventor(s): John Toscano, Saghar Nourian, Daryl Guthrie Unmet NeedAn estimated 17.9 million people died from cardiovascular diseases in 2019, representing 32% of all global deaths (see WHO). Nitroglycerin has been used as a vasodilator to treat heart conditions for over 130 years. It wasn't until 2003 that scientists realized the beneficial...

Published: 5/9/2024 | Inventor(s): John Toscano, Saghar Nourian, Daryl Guthrie

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

Hydroxylamine-substituted Alkyl Barbituric Acid Derivatives as Unexpected HNO Donors

#C12922Inventor(s): John Toscano, Daryl GuthrieUnmet NeedAn estimated 17.9 million people died from cardiovascular diseases in 2019, representing 32% of all global deaths (see WHO). Nitroglycerin has been used as a vasodilator to treat heart conditions for over 130 years. It wasn't until 2003 that scientists realized the beneficial effect was due...

Published: 5/9/2024 | Inventor(s): Daryl Guthrie, John Toscano

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Adverse Drug Reaction Prediction Model Using Physiological Signals Data

Unmet NeedAdverse drug reactions (ADR) are a major cause of death in the United States, with an estimated 100,000+ deaths and $40 billion in medical costs annually. Carvedilol is a beta-blocker that is prescribed over 20 million times annually and is used to treat patients with congestive heart failure. The drug is typically most effective when taken...

Published: 5/10/2024 | Inventor(s): Ali Afshar, Han Kim, Howard Burkom, Jason Lee

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Machine Learning, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure

VAD Care App 1.0

Unmet NeedLeft Ventricular Assist Devices have increased in their utilization over five-fold since 2003. Despite the massive increase in utilization there are still challenges to the management of LVAD systems. The goal for LVAD patients is that they will be able to achieve a level of self-management (SM) for patients with their LVADs. However, that...

Published: 5/9/2024 | Inventor(s): Jesus Casida

Keywords(s): Cardiovascular Diseases, Computer and Network Systems, Computer Software, Congestive Heart Failure (CHF), Database Management Software, Disease Indication, Disease Management System, Healthcare Management, Operations Management

Category(s): Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Medical Devices > Cardiology

An Imaging Toolbox for Guiding Cardiac Resynchronization Therapy Implantation from Patient-Specific Computed Tomography and Body Surface Potential Mapping Data

Guiding Cardiac Resynchronization Therapy ImplantationJHU REF: C12672Invention novelty: This method is for evaluating cardiac properties from Computed Tomography (CT) scan combined with Body Surface Potential Mapping (BSPM). Value Proposition:Heart failure is a major public health problem in the United States that affects 5 million people and contributes...

Published: 5/9/2024 | Inventor(s): Amir Pourmorteza, Elliott Mcveigh, Albert Lardo, Karl Schuleri, Fady Dawoud

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, Implantation Method, Implants, In Vivo Medical Imaging, Therapeutic Devices, Therapeutics, X-ray Computed Tomography (CT), X-Ray Computed Tomography (CT)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Method to Improve Heart Failure by Restoration of Synchronous Contraction after Period of Dyssynchrony

C11275: Novel Method to Restore Synchronous Contraction in Heart FailureNovelty: This technology provides a pharmacological approach to mimic Cardiac Resynchronization Therapy (CRT) without artificial electric stimulation.Value Proposition: This invention provides potential improvement in heart failure patients whose hearts are synchronous or dyssynchronous....

Published: 5/9/2024 | Inventor(s): David Kass, Jonathan Kirk, Gordon Tomaselli

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Electrical Stimulation Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices

A Congestive Heart Failure Management Program

C09996: A Congestive Heart Failure Management ProgramNovelty: This program uses patient variables to determine optimal treatment plans for patients with congestive heart failure.Value Proposition: Congestive heart failure (CHF) is a final common pathway for patients with a variety of cardiovascular diseases and is one of the most frequent admitting...

Published: 5/9/2024 | Inventor(s): Ronald Berger, Gary Gerstenblith, Kenneth Baughman

Keywords(s): Cardiovascular Diseases, Clinical Diagnostics, Congestive Heart Failure, Congestive Heart Failure (CHF), Diagnostic Tool, Disease Indication, Disease Management System, Healthcare Management, Operations Management, Screening Questionnaire

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software

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