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Artifact Control and Miniaturization of the Safe DC Stimulator for Neural Prostheses

Safe DC Stimulator for Neural ProsthesesJHU Ref #: [C11822] Unmet NeedCurrently, neural prostheses are limited because they excite neurons but cannot efficiently inhibit them. Direct current (DC) can excite, inhibit, or control extracellular potential of target neurons, but DC stimulation is biologically unsafe. The current solution is to direct DC...

Published: 5/9/2024 | Inventor(s): Charles Della Santina, Gene Fridman

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuroprosthetic Sensing Algorithms, Neuroprosthetics, Prosthetics, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Prosthetics, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 5/10/2024 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Johns Hopkins Stress Reduction Program

Unmet NeedWorkplace stress and its damaging knock-on effects are becoming increasingly prevalent in the United States. Approximately 40% of workers regard their job as being “very stressful” or “extremely stressful” (see American Institute for Stress). In addition to its adverse effects on mental health, long-term exposure to high levels of stress can...

Published: 5/10/2024 | Inventor(s): Neda Gould

Keywords(s):

Category(s): Copyright, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Psychiatry > Anxiety

Closed-loop Peripheral Nerve Stimulation for Restoration in Chronic Pain

Unmet NeedChronic pain affects about 100-million adults in the United States and is primarily treated with drugs, which can have significant negative side effects (NIH-Institute of Medicine). A promising alternative therapy is electrical peripheral nerve stimulation (PNS) therapy. However, PNS therapy has been associated with suboptimal efficacy because...

Published: 5/10/2024 | Inventor(s): Sridevi Sarma, Christine Beauchene, Yun Guan, Claire Zurn

Keywords(s):

Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices

Targeted Compression Stockings

Unmet NeedMore than 23% of all adults are thought to be affected by varicose veins. These veins are enlarged and swollen as a result of faulty valves that allow blood to flow in the wrong direction. Currently, varicose veins are managed through the application of a compression garment such as a stocking. The garments help prevent veins from being engorged...

Published: 5/9/2024 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cardiovascular Diseases, Disease Indication, Other, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular

Fluid Eluting Orthopaedic Implants with Chamber Empty Rate Determined through Topology Optimization

Unmet Need: The current designs of weightbearing orthopaedic implants are limited due to the variabilities in the material and structural properties of the bones in which they are implanted. In addition, many orthopaedic conditions -- and the implantation of foreign materials into the body -- are associated with significant risk of complications including...

Published: 5/9/2024 | Inventor(s): Jarred Bressner, Mikhail Osanov, Adam Levin

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices

Cell Impregnated Nanofiber Stent Sleeve ("CINSS") for Intravascular Growth Factor Production

Invention novelty:Stem cells are harnessed to create a stent-based “paracrine factor factory” using a novel biodegradable nanofiber sleeve which protects the cells from washout and immune attack, and provides a sheltered in vivo on-stent milieu for the cells to continuously produce and deliver healing growth factors and exosomes to injured tissue.Value...

Published: 5/9/2024 | Inventor(s): Chao-Wei Hwang, Zhiyong Xia, Virginia Bogdan, Jeffrey Brinker, Gary Gerstenblith, Peter Johnston, Steven Schulman, Gordon Tomaselli, Robert Weiss

Keywords(s): Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Stent, Therapeutic Devices, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Hollow, Perfusable Small-Diameter Tissue Engineered Vascular Grafts

Unmet NeedCardiovascular disease, often called “heart disease,” refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack. Approximately 43% of all cardiovascular disease cases involve coronary artery disease (CAD) and require coronary artery bypass surgery. Implantation of vascular grafts is the most common...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Morgan Elliott, Brian Ginn, Sebastian Barreto Ortiz, Hai-Quan Mao

Keywords(s): Cardiovascular Diseases, Coronary Heart Disease, Disease Indication, Implanted Device, Implants, Peripheral Artery Disease, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Vascular Diseases

Category(s): Clinical and Disease Specializations, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Coronary Heart Disease, Clinical and Disease Specializations > Cardiovascular > Peripheral Artery Disease, Clinical and Disease Specializations > Cardiovascular > Vascular Diseases

Artificial Corneal Device

Unmet NeedCorneal blindness affects an estimated 10 million people worldwide, particularly prevalent in the underdeveloped world. Currently, only about 10% of patients receive a corneal transplant due to a shortage of human donor corneas and difficulty in preserving the tissues. Meanwhile, even in countries with a sufficient donor supply, some patients...

Published: 5/9/2024 | Inventor(s): Esen Akpek, Gopalan Balaji, Thomas Schmiedel, Anuraag Singh

Keywords(s): Carriers/Appliers, Disease Indication, Eye Disorders, Implantation Method, Implants, Interventional and Surgical Systems, Surgical Instruments, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Ophthalmology

Implantable lens capsule for intraocular lens insertion.

Unmet NeedCataract surgery is the most common intraocular surgery, with more than 3.5 million occurring each year in the U.S. Various circumstances compromise the ability to safely insert an intraocular lens (IOL) implant following cataract extraction such as zonular insufficiency or posterior capsule rupture. Alternatives for IOL placement within the...

Published: 5/9/2024 | Inventor(s): Albert Jun, Angela Zhu, Peter Gehlbach

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

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