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Dynamic Hydrogels

Unmet NeedOrgan/tissue regeneration remains a major area of research with few viable clinical products. A major barrier is the development of biologically accurate tissue constructs, with vascularization being a primary component. Classic static hydrogels have non-reversible crosslinks such that network is elastic at the macro-scale but limited in response...

Published: 5/10/2024 | Inventor(s): Sharon Gerecht, Rahel Schnellmann, Zhao Wei, Eugenia Volkova

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Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing

Unmet Need:Third-degree burns involve damage to both the epidermal and dermal layers and may also entail damage to underlying muscles, bones, and tendons. Such burns heal with thick scars, which result in contractures that distort the surrounding tissue. Deep third-degree burns usually require skin grafting to achieve wound closure, but the cosmetic...

Published: 5/9/2024 | Inventor(s): Guoming Sun, Xianjie Zhang, John Harmon, Sharon Gerecht

Keywords(s): Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Hollow, Perfusable Small-Diameter Tissue Engineered Vascular Grafts

Unmet NeedCardiovascular disease, often called “heart disease,” refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack. Approximately 43% of all cardiovascular disease cases involve coronary artery disease (CAD) and require coronary artery bypass surgery. Implantation of vascular grafts is the most common...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Morgan Elliott, Brian Ginn, Sebastian Barreto Ortiz, Hai-Quan Mao

Keywords(s): Cardiovascular Diseases, Coronary Heart Disease, Disease Indication, Implanted Device, Implants, Peripheral Artery Disease, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Vascular Diseases

Category(s): Clinical and Disease Specializations, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Coronary Heart Disease, Clinical and Disease Specializations > Cardiovascular > Peripheral Artery Disease, Clinical and Disease Specializations > Cardiovascular > Vascular Diseases

Self-organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix

Unmet NeedTissue regeneration is a large part of a huge market for redeveloping tissues that have been damaged or have lost functionality. The success of tissue regenerative therapies is dependent on functional and multicellular vasculature within the redeveloping tissue. The problem with human endothelial cells (EC), which line the vasculature’s inner...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Sravanti Kusuma

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Oxygen Gradient Hydrogels to Study and Screen Potential Cancer Therapeutics

Unmet needHypoxia is a critical factor in the progression and metastasis of many cancers. Frequently, oxygen gradients develop in tumors as they grow beyond their vascular supply leading to heterogeneous areas of oxygen depletion.Technology OverviewJohns Hopkins researchers have created a gradient hydrogel (collagen and gelatin) and observed that hypoxic...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Daniel Lewis, Kyung Min Park, Tzipora Sarah Eisinger, M. Simon

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Three-dimensional Vascular Network Assembly from Diabetic Patient-derived Induced Pluripotent Stem Cells

In diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer three-dimensional (3D) vascular networks in synthetic hydrogels from type-1 diabetes (T1D) patient-derived human induced pluripotent stem cells (hiPSCs), thus serving as a transformative autologous vascular...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Xin Yi Chan, Quinton Smith, Yu-I Shen

Keywords(s): Biologics, Cell Model, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Stem Cells

Hypoxia-inducible Hydrogels

Hypoxia, low oxygen tension, plays a pivotal role during development, regeneration, and cancer. However, nobody has stimulated hypoxia in a 3D microenvironment. Here, we developed a fundamental technology to create hydrogel materials that can serve as 3D hypoxic microenvironments. The HI hydrogels are formed via oxygen consumption in a laccase-mediated...

Published: 5/9/2024 | Inventor(s): Kyung Min Park, Sharon Gerecht

Keywords(s): Bioreactor-based Manufacturing, Disease Indication, Implanted Device, Implants, Industrial Manufacturing, Manufacturing Method, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Industrial Tech, Technology Classifications > Medical Devices, Technology Classifications > Engineering Tech > Industrial Manufacturing

Guiding the Derivation of Endothelial Cells from Human Pluripotent Stem Cells in a Two-dimensional, Feeder Free Differentiation Scheme

New defined chemical method for growth of endothelial cells from human stem cellsJHU REF: [C11924]Invention novelty: Development of defined chemical conditions and method for culturing of endothelial cells (ECs) from human embryonic and induced pluripotent stem cells using sequential adherent cell culture method. Value PropositionThe development of...

Published: 5/9/2024 | Inventor(s): Sravanti Kusuma, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Cell Model, Culture Media, Discovery/Research Tools, In Vitro Research Tool, Research Reagent, Stem Cells, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Smooth-muscle-like-cells (SMLCs) Derived from Human Embryonic Stem Cells (hESCs) Support Cord-like Structure in vitro

This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into smooth muscle-like cells (SMLCs) in vitro, comprising a) plating a single-cell suspension of PSCs that are smaller than 50 μm at a seeding concentration of about 5×104 cells/cm2-about 1×105 cells/cm2 onto a suitable surface, and culturing...

Published: 5/9/2024 | Inventor(s): Sharon Gerecht, Maureen Wanjare, Elaine Vo, Donny Hanjaya-Putra

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Human Cell Lines, Implanted Device, Implants, In Vitro Research Tool, Stem Cells, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Human Cell Lines

Electro-mechanically Stretched Micro Fibers and Methods of Use

C11956: Improved Stretched Microfiber ProductionNovelty: This technology is a new method for producing stretched microfibers with smaller, more consistent diameters.Value Proposition: While there are numerous known applications for microfibers, current fabrication methods lack a significant amount of control. These primarily consist of using a high...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Shuming Zhang, Xi Liu, Brian Ginn, Sharon Gerecht, Sebastian Barreto Ortiz

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities