Search Results - target-based+screening+tool

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Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 5/9/2024 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

A Novel mAb20-based In-cell ZnT8 Assay

Unmet Need: Prevalence of Type 2 Diabetes (T2D) continues to rapidly increase worldwide, contributing significant economic and global health burdens. There is an urgent need for the development of novel therapeutic strategies to treat T2D.Technical Details: Johns Hopkins researchers have identified a novel target to treat T2D and report here the development...

Published: 5/9/2024 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Analytical Method, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Proteomics/Immunoassays, Research Reagent, Target-based Screening Tool, Type II Diabetes

Category(s): Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

An ex vivo Model for Rapid Evaluation of Choroidal Mast Cell Degranulation

Unmet NeedAlmost 11 million people in the United States have symptoms of age-related macular degeneration (AMD). AMD is a multifactorial disease distinguished by progressive degeneration in the macular region of the eye, resulting in irreversible central vision loss among the elderly population. Current evidence suggests that inflammation plays a vital...

Published: 5/9/2024 | Inventor(s): Gerard Lutty, Shuntaro Ogura

Keywords(s): Discovery/Research Tools, Disease Indication, Eye Disorders, In Vitro Research Tool, In Vivo Research Tool, Macular Degeneration, Rat Model, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Dry Age-Related Macular Degeneration

Simulation Prediction of Optimal Targets for Catheter Ablation of Left Atrial Flutter in Patients with Atrial Structural Remodeling

Unmet NeedLeft atrial flutter (LAFL) is a common atrial arrhythmia that develops in up to 31% of patients who had prior cardiac surgery or atrial fibrillation ablation. LAFL is caused by the presence of a reentrant circuit, which occurs when an electrical impulse continues to propagate and re-excite cardiac tissue, leading to uncoordinated, repeated...

Published: 5/9/2024 | Inventor(s): Natalia Trayanova, Sohail Zahid, Patrick Boyle

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Using Patient-Specific Modeling of the Heart for Prediction of Optimal Targets for Catheter Ablation of Ventricular Tachycardia in Patients with Myocardial Infarction or Fibrosis and ICDs

Unmet NeedVentricular tachycardia (VT) is a heart rhythm disorder that affects hundreds of thousands of Americans every year. VT is defined as an irregular accelerated heart rate due to abnormal electrical signaling in the heart’s lower chambers. Implantable Cardioverter Defibrillators (ICDs) can protect high-risk patients from sudden cardiac arrest...

Published: 5/9/2024 | Inventor(s): Natalia Trayanova, Sohail Zahid, Adityo Prakosa

Keywords(s): Discovery/Research Tools, Heat Intervention, In Vitro Research Tool, Interventional and Surgical Systems, Surgical Intervention Method, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

High-throughput microfluidic platform for high-density immobilization and parallelized quantitative real-time measurements of droplets

Unmet Need:Droplet platforms, which compartmentalize samples into encapsulated droplets for high-throughput analysis, have been used to detect and analyze diverse molecules, including nucleic acids, proteins, and single cells, at a higher sensitivity than traditional methods. Despite advantages in sensitivity and throughput, most existing droplet analysis...

Published: 5/9/2024 | Inventor(s): Tza-Huei (Goes by Jeff) Wang, Christine O'Keefe, Aniruddha Kaushik

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays

Biomarkers of Therapeutic Response in Ovarian Cancer

Unmet NeedOvarian cancer is the most common cause of death among gynecological cancers and is associated with poor outcomes and low overall survival rates. The current standard of care involves surgical resection of the solid tumor, followed by chemotherapy. This type of therapy has limited success among women with advanced disease, and often results...

Published: 5/9/2024 | Inventor(s): Victor Velculescu, Robert Scharpf, Eniko Papp, Dorothy Hallberg, Dennis Slamon, Gottfried Konecny

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Ovarian Cancer, Target-based Screening Tool

Category(s): Clinical and Disease Specializations > Oncology > Ovarian Cancer

A CRISPR-based yeast two-hybrid system for investigating RNA-protein interaction

Unmet Need: DNA-sequencing technology has led to the development of many powerful techniques, such as RIP-seq and CLIP-seq, which can be used to identify many RNAs bound by a protein of interest, however, few protocols exist for identifying the proteins bound to a particular RNA. Most available techniques involve RNA pull-down followed by protein identification...

Published: 5/9/2024 | Inventor(s): David Zappulla, Evan Hass

Keywords(s): Analytical Method, Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Target-based Screening Tool, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics

ESR1 Mutations in Human Breast Cancer Cells

TITLE ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns...

Published: 5/9/2024 | Inventor(s): David Chu, Ben Ho Park

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Target-based Screening Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 5/9/2024 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

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