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Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 5/9/2024 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cell Lines with Inducible LINE-1

Unmet NeedIn the United States, approximately 1.9-million new cancer cases are projected to be diagnosed with 608,570 cancer deaths in 2021 (see ACS). Early screening initiatives that detect cancer as well as novel therapeutics that target and destroy tumor cells may lead to a future decrease in the number of cancer-related mortality. To improve the...

Published: 5/10/2024 | Inventor(s): Kathleen Burns, Andrew Holland, Daniel Ardeljan

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Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 5/10/2024 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

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Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

Inducible OGT Knockout Cell Line

Marketing Summary DraftInducible OGT Knock-out Cell LineJHU Ref #: C17974Value Proposition· Mouse embryonic fibroblast cell line· Rapid and reproducible depletion of essential OGT gene· Enables O-GlcNAc modification studiesUnmet Need· O-GlcNAcylation (O-GlcNAc) is a nutrient- and stress-responsive post-translational modification...

Published: 5/10/2024 | Inventor(s): Natasha Zachara, Hana Chang, Michael Wolfgang, Zahra Kazemi

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Category(s): Technology Classifications, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

Clinical-Grade Therapeutic Progenitors Generated from Universal Donor Tankyrase/PARP-Inhibited Pluripotent Stem Cell Banks

Unmet Need / Invention Novelty: Regenerative cell therapies with conventional, lineage-primed human induced pluripotent stem cells (hiPSC) are limited by variable differentiation efficiency and poor in vivo functionality. There is an unmet need to establish novel methods for efficiently generating functional and transplantable therapeutic progenitors. Technical...

Published: 5/10/2024 | Inventor(s): Elias Zambidis, Ludovic Zimmerlin

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Research Stem Cells

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 5/10/2024 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

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Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 5/9/2024 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Monoclonal Antibodies Specific to AGK, for Research Purposes

Unmet Need: Acylglycerol kinase, AGK, is a protein in the TIMM22 translocon and is postulated to be important in cardiolipin biogenesis. Mutations in the gene encoding for AGK also can result in human disease, making the study of the protein important in understanding disease pathogenesis. Currently there are no validated human AGK specific antibodies,...

Published: 5/10/2024 | Inventor(s): Steven Claypool

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Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Metabolic Diseases

Monoclonal Antibody Specific to Human ANT1, for Research Purposes

Unmet Need: ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is a protein important for mitochondrial energy production and is relevant in the research of human mitochondrial diseases. Mutations in the gene encoding for ANT1 also can result in human disease, making the study of the protein important in understanding disease pathogenesis....

Published: 5/10/2024 | Inventor(s): Steven Claypool

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Metabolic Diseases

Isogenic SF3B1 cell lines for drug discovery

SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...

Published: 5/9/2024 | Inventor(s): Ben Ho Park, William Dalton

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines

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