Search Results - technology+classifications

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Recombinant anti-PAD4 antibodies as a treatment for lung fibrosis

Value PropositionSelective monoclonal antibody therapy to treat lung fibrosis.Directly targets immune cells to promote a pro-inflammatory pathway that reduces fibrosis.High serum levels are associated with less severe lung disease, decreased fibrosis, and improved survival in a subset of rheumatoid arthritis patients.Broadly applicable to other diseases...

Published: 5/10/2024 | Inventor(s): Erika Darrah, Felipe Andrade, Kristen Demoruelle, Elizabeth Redente

Keywords(s):

Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications, Technology Classifications > Therapeutic Modalities

Col3a1G938D heterozygous mice

Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...

Published: 5/10/2024 | Inventor(s): Harry Dietz, Caitlin Bowen

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

DOPA and Caffeic Acid Analogs as Novel GCPII Inhibitors

Unmet NeedGlutamate is the primary excitatory neurotransmitter in the human brain [1]. Excessive glutamate signaling can disrupt calcium homeostasis, leading to mitochondrial dysfunction, the overproduction of reactive oxygen species, and neuron loss via necrotic or apoptotic pathways [2]. This phenomenon, known as excitotoxicity, contributes to disease...

Published: 5/10/2024 | Inventor(s): Barbara Slusher, Rana Rais, Takashi Tsukamoto

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules

Photoacoustic Tumor Bed Imaging in Breast Conserving Surgery

Method for identifying residual breast cancer cells following tumor removalJHU Ref #: C17840Value Proposition· Enables medical professionals to identify residual tumor cells for removal in real-time· Reduces time and cost by eliminating need for post-operative analysis of excised tissue· Safe and radiation-free alternative to other...

Published: 5/10/2024 | Inventor(s): Russell Taylor, Emad Boctor, Laura Connolly, Gabor Fichtinger, Parvin Mousavi

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications, Technology Classifications > Medical Devices > Imaging

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 5/10/2024 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

Modulation of Oxidative Stress as a Therapeutic Pathway in Trigeminal Neuralgia

Unmet NeedTrigeminal neuralgia is a condition that affects the fifth cranial nerve, caused either via trigeminal nerve compression or secondary to another medical condition (i.e., multiple sclerosis, facial injury, tumors, etc.). Trigeminal neuralgia results in severe orofacial pain that is exceptionally debilitating, with a profound effect on one’s...

Published: 5/10/2024 | Inventor(s): Michael Lim, Solomon Snyder, Risheng Xu, Chirag Vasavda, Ryan Dhindsa

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications, Technology Classifications > Therapeutic Modalities > Small Molecules

Inducible OGT Knockout Cell Line

Marketing Summary DraftInducible OGT Knock-out Cell LineJHU Ref #: C17974Value Proposition· Mouse embryonic fibroblast cell line· Rapid and reproducible depletion of essential OGT gene· Enables O-GlcNAc modification studiesUnmet Need· O-GlcNAcylation (O-GlcNAc) is a nutrient- and stress-responsive post-translational modification...

Published: 5/10/2024 | Inventor(s): Natasha Zachara, Hana Chang, Michael Wolfgang, Zahra Kazemi

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

Interferential Current Stimulator for Peripheral Nerves

Technology Description· Researchers at Johns Hopkins have developed a small, wireless, implantable device for the treatment of neurologic disorders (e.g., epilepsy, Parkinsons).· This device includes only the minimum circuitry required for stimulation, reducing negative side effects associated with standard tethered cuff electrodes.· The...

Published: 5/15/2024 | Inventor(s): Ryan Budde, Pedro Irazoqui, Michael Williams

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Epilepsy, Technology Classifications, Technology Classifications > Medical Devices > Neurostimulation

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 5/10/2024 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Continuous Ultrasound Imaging for Monitoring of Structures and Their Function under Normal and Pathologic Conditions

Continuous Ultrasound Imaging with AI for Diagnosis of Deep Vein Thrombosis (DVT) JHU Ref #: C17510 Value PropositionContinuous ultrasound imaging of blood vessels in the leg to detect abnormalities in blood flow.This technology uses artificial intelligence (AI) to monitor ultrasound images and assess the risk and diagnose deep vein thrombosis early.Current...

Published: 5/10/2024 | Inventor(s): Aliaksei Pustavoitau, Amir Manbachi, Kaushik Sampath, James Wissman, Haley Abramson, Joshua Punnoose, Kelley Leadingham

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

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