Search Results - clinical+and+disease+specializations+%3e+neurology+%3e+epilepsy

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Interferential Current Stimulator for Peripheral Nerves

Technology Description· Researchers at Johns Hopkins have developed a small, wireless, implantable device for the treatment of neurologic disorders (e.g., epilepsy, Parkinsons).· This device includes only the minimum circuitry required for stimulation, reducing negative side effects associated with standard tethered cuff electrodes.· The...

Published: 5/15/2024 | Inventor(s): Ryan Budde, Pedro Irazoqui, Michael Williams

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Epilepsy, Technology Classifications, Technology Classifications > Medical Devices > Neurostimulation

Rufinamide derivatives as novel drugs against epilepsy syndromes caused by aberrant sodium channel behavior

Unmet NeedLennox-Gastaut Syndrome (LGS) is rare and severe form of childhood-onset epilepsy associated with various types of seizures and cognitive dysfunction that persist into adulthood; yet, to date, LGS management is challenged by the lack of reliable diagnostic tests and potentially grave side-effects of available therapeutics. Rufinamide is a...

Published: 5/9/2024 | Inventor(s): Frank Bosmans, Dimpy Kalia

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Epilepsy, Genetic Disorders, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Epilepsy, Clinical and Disease Specializations > Rare Diseases

Virtual Cortical Stimulation Mapping for Epileptogenic Zone Localization

Unmet NeedCortical stimulation mapping is an electrocorticography monitoring that involves a surgically invasive clinical procedure. Its purpose serves to localize functions of specific cerebral regions of the brain through electrical stimulation of a cerebral cortex. During cortical stimulation mapping, electrodes are placed directly on to the cerebral...

Published: 5/9/2024 | Inventor(s): Sridevi Sarma, Adam Li

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Neurology > Epilepsy

Method for Treating Refractory Seizures Using a Novel Therapeutic Approach

Technology OverviewThe invention provides novel pharmaceutical interventions that convert phenobarbital (PB)-resistant seizures into phenobarbital responsive seizures in neonates. We have shown that unlike in adult brains, expression of a transport protein in the neonatal brain is much lower and undergoes further down-regulation following an ischemic...

Published: 5/9/2024 | Inventor(s): Shilpa Kadam

Keywords(s): Agonists/Promoters, CNS and Neurological Disorders, Disease Indication, Epilepsy, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Epilepsy, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Novel Triazole Compounds to Treat Nav1.6-related Brain Disorders

Unmet NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of epilepsy syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target...

Published: 5/9/2024 | Inventor(s): Frank Bosmans, Dimpy Kalia

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Epilepsy, Neuropathy, Non-novel, Novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Neurology > Epilepsy

Novel Triazole Compounds to Treat Brain Disorders

Published: 5/9/2024 | Inventor(s): Frank Bosmans, Jeet Kalia

Keywords(s): Antagonists/Inhibitors, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epilepsy, In Vitro Diagnostics, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Epilepsy, Technology Classifications > Research Tools > Assays