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Antisense oligonucleotide therapy and biomarker assay for C9ORF72 hexanucleotide expansion disorders

Therapy to Treat and Assay to Monitor Neurodegenerative Disease JHU REF: [C12195]Invention novelty: This technology is the use of antisense oligonucleotides (ASO) as a therapeutic for specific neurodegenerative diseases. The technology could also be used in development of a biomarker assay to monitor the efficacy of the ASO therapy. Value Proposition: Current...

Published: 5/9/2024 | Inventor(s): Christopher Donnelly, C. Bennett, Susan Freier, Rita Sattler, Jeffrey Rothstein

Keywords(s): Amyotrophic Lateral Sclerosis, Assay, Biologics, Clinical Diagnostics, CNS and Neurological Disorders, Dementia, Disease Indication, In Vitro Diagnostics, Neurodegeneration, Nucleic Acid, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration

Urinary Glycoproteins for the Early Detection of Aggressive Prostate Cancer

Unmet NeedAccording to the American Cancer Society, prostate cancer is one of the most commonly diagnosed cancers and is the second leading cause of cancer death in men. However, most patients with prostate cancer have the low-risk, nonaggressive form that does not require invasive intervention or treatment. The gold standard of diagnosing men with...

Published: 5/9/2024 | Inventor(s): Hui Zhang, Mingming Dong, Tung-Shing Lih

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prostate Cancer

Category(s): Technology Classifications > Diagnostics > Prognostic Biomarkers, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics

Detection of PAR for a Diagnosis in the CSF of Parkinson’s Disease (PD) Patients

Unmet Need Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a gradual loss of all motor function. Currently, no diagnostic test exists for PD. Nevertheless, the early diagnosis of PD is critical for successful disease management as pharmacological treatments like levodopa are most effective when administered at the earliest...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Tae-In Kam, Liana Rosenthal, Shaida Andrabi

Keywords(s): Assay, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Detection of circulating methylated DNA for high-sensitivity cancer diagnostic and treatment planning

Unmet Need / Invention Novelty: Circulating tumor-associated methylated DNA is an important biomarker for early detection of cancer, risk assessment, predicting and monitoring response to therapy and early detection of relapse. Current tests designed to detect methylated tumor DNA in patient fluids such as the serum and plasma are challenged by low...

Published: 5/9/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Antonio Wolff, Zoila Lopez Bujanda, Wei Wen Teo

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test

There is a crucial need of discovering novel biomarkers in addition to prostate specific antigen (PSA) to improve the specificity of clinical diagnosis for prostate cancer. This invention addresses this problem by discovering proteins from prostate cancer tissues that can be detected in patients’ blood. Hence, a blood test can be developed for detecting...

Published: 5/9/2024 | Inventor(s): Yan Li, Daniel Chan, Zhen Zhang, Lori Sokoll, Hui Zhang

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 5/9/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Global DNA Hypomethylation as Biomarker for Clinical Detection, Inflammation Severity, and Disease Progression in Gastric Cancer

C11444: Novel Biomarker for Diagnosis of Gastric CancerNovelty: The reported technology identifies a novel biomarker for clinical detection, inflammation severity, and disease progression in gastric cancer.Value Proposition: The technology outlined is a diagnostic technique to detect a biomarker known to play a major role in gastric carcinogenesis....

Published: 5/9/2024 | Inventor(s): David Sidransky, Rafael Guerrero-Preston

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Gastric Cancer, In Vitro Diagnostics, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Gastric Cancer

miRNA Analysis Method

#C11885: miRNA Analysis MethodUnmet NeedThe gold standard for miRNA profiling is quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). While qRT-PCR is fast, reproducible, and can handle smaller input samples than other profiling methods (Chugh et al.), it can only evaluate less than 10 miRNAs at a time. Other methods can profile thousands...

Published: 5/9/2024 | Inventor(s): Yunke Song, Kelvin Liu, Tza-Huei (Goes by Jeff) Wang

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

EXoO-Tn Tag-n-Pin the Pan-Carcinoma Tn Antigen in Human Proteome

Unmet NeedAberrant glycosylation has been implicated as a mechanism of cancer progression. Accordingly, identifying the differences in glycan structures within clinical specimens, cancer, and normal cells provides a unique opportunity to identify new biomarkers and therapeutic targets. In particular, Tn antigen (Tn) is a simple O-linked glycan structure...

Published: 5/9/2024 | Inventor(s): Hui Zhang, Weiming Yang

Keywords(s): Analytical Method, Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, Pancreatic Cancer, Pancreatic ductal adenocarcinoma

Category(s): Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

An ECL-based Autoantibody Assay for Early Diagnosis of T1D Using a Membrane-spanning ZnT8 Antigenic Domain

Unmet NeedApproximately 1.25 million people in the US have type 1 diabetes (T1D) and the rates of newly diagnosed cases in children are on the rise each year. T1D is caused by the development of an autoimmune reaction to pancreatic β cells. The first detectable sign of β cell autoimmunity is the appearance of diabetes-associated autoantibodies, which...

Published: 5/9/2024 | Inventor(s): Dax Fu, Chengfeng Merriman, Liping Yu, Yong Gu

Keywords(s): Assay, Biomarker, Clinical Diagnostics, Diabetes, Diagnostic Biomarker, Diagnostic Tool, Disease Indication, In Vitro Diagnostics (Old), Measurement Tool, Metabolic Disorders, Type II Diabetes

Category(s): Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Diagnostics > Diagnostic Biomarkers

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