Search Results - neurodegeneration

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Novel Therapeutic Drug for Multiple Sclerosis

INVENTION NOVELTY This molecule, through its action on a unique target that is different from current therapeutic treatments for MS, has both immunosuppressive and neuromodulatory properties that will better prevent the progression of MS and repair the neuronal damage caused by the immune cells in MS. Currently, there are no MS drugs in the market...

Published: 5/9/2024 | Inventor(s): Paul Kim, Michael Kornberg, Peter Calabresi, Solomon Snyder

Keywords(s): Chronic Inflammatory Diseases, CNS and Neurological Disorders, Disease Indication, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Antisense oligonucleotide therapy and biomarker assay for C9ORF72 hexanucleotide expansion disorders

Therapy to Treat and Assay to Monitor Neurodegenerative Disease JHU REF: [C12195]Invention novelty: This technology is the use of antisense oligonucleotides (ASO) as a therapeutic for specific neurodegenerative diseases. The technology could also be used in development of a biomarker assay to monitor the efficacy of the ASO therapy. Value Proposition: Current...

Published: 5/9/2024 | Inventor(s): Christopher Donnelly, C. Bennett, Susan Freier, Rita Sattler, Jeffrey Rothstein

Keywords(s): Amyotrophic Lateral Sclerosis, Assay, Biologics, Clinical Diagnostics, CNS and Neurological Disorders, Dementia, Disease Indication, In Vitro Diagnostics, Neurodegeneration, Nucleic Acid, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration

Maximizing Independence at Home Dementia Care Coordination Program (MIND at Home)

Unmet NeedDementia is a leading cause of dependency and mental impairment among the elderly population, one of the most costly chronic conditions in the U.S., and ranks as the 5th leading cause of death among persons 65 and over. Over 70% of the 5.4 million Americans who suffer from dementia are cared for at home by an estimated 15 million informal...

Published: 5/9/2024 | Inventor(s): Peter Rabins, Mary Johnston, Betty Black, Constantine Lyketsos, Quincy Samus

Keywords(s): CNS and Neurological Disorders, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Dementia, Disease Indication, Neurodegeneration, Physics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration

Dementia Risk Assessment

Unmet NeedWith 9.9 million new cases each year, more than 47 million people worldwide have dementia. To detect dementia, questionnaires and cognitive screening tests are administered. Physicians diagnose dementia based on medical history, in-person examinations, brain imaging and blood tests. The global societal cost of dementia in 2015 was estimated...

Published: 5/9/2024 | Inventor(s): Jason Brandt

Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 5/9/2024 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 5/9/2024 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

A Highly Accurate Fundus Classification Method and Apparatus for Grading of the Advance of Age Related Macular Degeneration

A method of detecting, and classifying severity of, a retinal disease using retinal images includes at least one of receiving, retrieving or generating reference data that includes information concerning occurrences of key image features for each of a plurality of retinal disease and disease severity conditions; receiving a retinal image of an individual;...

Published: 5/9/2024 | Inventor(s): Srihari Kankanahalli, David Freund, Philippe Burlina, Neil Bressler

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Eye Disorders, Macular Degeneration, Measurement Tool, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Diagnostics > Diagnostic Imaging

Biomarkers of Alzheimer's and other Diseases of Cognition

Unmet Need Alzheimer’s disease (AD) results in progressive loss of cognitive function. The common methods of AD diagnoses are clinical observations and medical imaging. As new therapies for AD are discovered, there is a need for simple biomarkers that can be related to the disease pathogenesis. Current biomarkers for AD are unreliable and are not highly...

Published: 5/9/2024 | Inventor(s): Paul Worley, Desheng Xu, Meifang Xiao

Keywords(s): Alzheimer's Disease, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology

Identification of a Novel AIF3 Isoform

TITLEIdentification of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5’ RACE. AIF3 lacks exons 2 and 3, which...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Masayuki Sasaki, Yingfei Wang

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Growth Factors, Neurodegeneration, Neurodegenerative Diseases, Recombinant Proteins, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Human immunoglobulin purified from NMO-IgG positive patient plasma

Purified Human IgG Antibodies from Positive NMO- IgG PatientJHU REF: [C12575]Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient. Value Proposition: NMO or Devic’s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific...

Published: 5/9/2024 | Inventor(s): Michael Levy

Keywords(s): Antibodies, Blood Samples, Buffer/Media Solution, Chronic Inflammatory Diseases, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Neuromyelitis Optica, Neuromyelitis optica (NMO), Optic Neuritis, Polyclonal Antibodies, Research Reagent, Translational Research Biomarker

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