Search Results - neurodegenerative+diseases

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Inhibition of rip kinases for treating neurodegenerative disorders

Unmet NeedNeurodegenerative disorders are a heterogeneous group that includes Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementia, and Huntington’s disease. These disorders result from progressive degeneration of the structure, function, and network of neurons in the central nervous...

Published: 5/9/2024 | Inventor(s): Seulki Lee, Han Seok Ko, Ted Dawson, Martin Pomper, Donghoon Kim, Yumin Oh, Seung-Hwan Kwon, Yong Joo Park

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Neurodegenerative Diseases, Parkinson's Disease, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

SARM1 Inhibition or Deletion as Experimental Treatment of Traumatic Brain Injury and Neurodegenerative Disease

Unmet NeedTraumatic brain injury (TBI) is regarded as one of the major causes of death and disability in the United States, contributing to 30% of all injury-related deaths. Over 150 people die daily from consequences of a TBI and those that survive often face difficulties and disabilities that can last for the duration of their lives. TBIs range in...

Published: 5/9/2024 | Inventor(s): Vassilis Koliatsos, Nikolaos Ziogas, Athanasios Alexandris, Jiwon Ryu

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neurodegenerative Diseases, Target, Therapeutic Matter, Therapeutics, Traumatic Injury

Category(s): Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Traumatic Injury

Identification of a Novel AIF3 Isoform

TITLEIdentification of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5’ RACE. AIF3 lacks exons 2 and 3, which...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Masayuki Sasaki, Yingfei Wang

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Growth Factors, Neurodegeneration, Neurodegenerative Diseases, Recombinant Proteins, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

HD-iPSC Lines

C11143: Huntingtons Disease Associated iPSC linesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from patients with Huntingtons disease (HD).Value Proposition: HD is a devastating and fatal hereditary neurodegenerative disorder with no current cure. Although numerous cell culture and animal models exist, the preferential neuron degeneration...

Published: 5/9/2024 | Inventor(s): Guo-li Ming, Russell Margolis, Christopher Ross, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Neurodegenerative Diseases, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Novel Compounds targeting GAPDH-Siah Cell Death Cascade

C11114: Novel Compounds targeting GAPDH-Siah Cell Death Cascade Novelty: The GAPDH (Glyceraldehyde-3-phosphate dehydrogenase)-Siah cell death cascade is a implicated in several stress mediated disorders and blocking this cascade using novel inhibitors is an attractive strategy for developing cytoprotective agents. Value Proposition: Cell death...

Published: 5/9/2024 | Inventor(s): Neelam Shahani, Toshiaki Saito, David Kass, Eiki Takimoto, Akira Sawa

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, Biomarker, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, Mechanism of Action Biomarker, Neurodegenerative Diseases, Non-novel, Novel, Predicted Novelty, Psychiatric Diseases, Repurposed, Schizophrenia, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Generation of Leucine-rich Repeat Kinase 2 (LRRK2) Wild-type, G2019S and R1441C Transgenic Mice

C10386: Generation of Leucine-rich Repeat Kinase 2 (LRRK2) Wild-type and mutant LRRK2 Transgenic MiceValue Proposition: Mutations in the Leucine-rich Repeat Kinase 2 (LRRK2) gene are a common cause of late-onset familial Parkinson's disease (PD) and mutations in LRRK2 are also associated with sporadic Parkinson's disease. These LRRK2 transgenic mice...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Darren Moore, Valina Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Neurodegenerative Diseases, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Neurodegeneration

Role of Limonoid Compounds As Neuroprotective Agents

Invention novelty: A series of compounds from the limonoid family that can be used in protecting neurons from different types of toxicity. Unmet Need: Neurodegenerative diseases are characterized by extensive deterioration of neurons or glia. Because these cells are not easily regenerated, there is an emerging unmet medical need for a therapeutic...

Published: 5/9/2024 | Inventor(s): Norman Haughey, Avindra Nath, Joseph Steiner

Keywords(s): CNS and Neurological Disorders, Disease Indication, Multiple CNS Indications, Natural compounds, Neurodegeneration, Neurodegenerative Diseases, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities