Search Results - norman+haughey

4 Results

Sort By:

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND)

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND) Marketing Summary: Polyamines are molecules, present in all organisms, whose concentrations are regulated by the enzyme Spermine/Spermidine Acetyl transferase (SSAT). SSAT works by inactivating polyamines. Once these polyamines are inactivated they are...

Published: 5/9/2024 | Inventor(s): Kamel Khalili, Carlos Barrero, Salim Merali, Jay Rappaport, Norman Haughey, Ned Sacktor

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders

Discovery of 2,6-Dimethoxy-4-(5-Phenyl-4-Thiophen-2-yl-1H-Imidazol-2-yl)-Phenol (DPTIP) a Small Molecule Inhibitor of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative and Oncologic Diseases

Unmet NeedAlzheimer’s disease (AD) is the most common form of dementia, affecting approximately 5.7 million people in the United States in 2018. Yet, no cure exists for AD, and AD therapeutics presently on the market fail to treat the disease’s underlying causes. Recent studies in mice reveal that exosomes released from glial cells contribute to the...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Camilo Rojas, Ajit Thomas, Norman Haughey, Marc Ferrer, Xin Hu

Keywords(s): Antagonists/Inhibitors, Cancers, CNS and Neurological Disorders, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules

Role of Limonoid Compounds As Neuroprotective Agents

Invention novelty: A series of compounds from the limonoid family that can be used in protecting neurons from different types of toxicity. Unmet Need: Neurodegenerative diseases are characterized by extensive deterioration of neurons or glia. Because these cells are not easily regenerated, there is an emerging unmet medical need for a therapeutic...

Published: 5/9/2024 | Inventor(s): Norman Haughey, Avindra Nath, Joseph Steiner

Keywords(s): CNS and Neurological Disorders, Disease Indication, Multiple CNS Indications, Natural compounds, Neurodegeneration, Neurodegenerative Diseases, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Diagnostic and Prognostic Markers and Treatment Strategies for Multiple Sclerosis

C04371: Novel Diagnostic and Prognostic Multiple Sclerosis Protein BiomarkerNovelty: A novel diagnostic and prognostic protein biomarker in Cerebral Spinal Fluid that is 100% specific for Multiple Sclerosis when compared to other neurologic disorders.Value Proposition: Current Multiple Sclerosis diagnosis is produced and confirmed strictly by clinical...

Published: 5/9/2024 | Inventor(s): Caroline Anderson, David Irani, Robert Cotter, Norman Haughey, Joseph Steiner, Avindra Nath

Keywords(s): Biomarker, Chronic Inflammatory Diseases, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Prognostic Biomarker