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Value Proposition· Target associated with viral load reduction identified from a large pool of study participants who had low level viremia· Potential to reduce disease severity in at-risk populations· Proactive approach to lower viral load in individuals who could become infected Unmet NeedHuman immunodeficiency virus (HIV) impacts millions...

Published: 5/10/2024 | Inventor(s): Susan Eshleman, Harry Larman, Kai Kammers, Oliver Laeyendecker, Wendy Grant-McAuley

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND)

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND) Marketing Summary: Polyamines are molecules, present in all organisms, whose concentrations are regulated by the enzyme Spermine/Spermidine Acetyl transferase (SSAT). SSAT works by inactivating polyamines. Once these polyamines are inactivated they are...

Published: 5/9/2024 | Inventor(s): Kamel Khalili, Carlos Barrero, Salim Merali, Jay Rappaport, Norman Haughey, Ned Sacktor

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders

Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 5/9/2024 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Polymer of Prodrug Methods for Sustained Release of Antivirals for Treatment or Prevention of HIV

Unmet Need:Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are amongst the most serious and challenging health problems in the world. There are nearly 37 million people worldwide living with HIV/AIDS and approximately 1 million AIDS-related deaths have occurred in 2017 alone - about 5,000 new infections per...

Published: 5/9/2024 | Inventor(s): Caren Freel Meyers, Steven Rannard, Andrew Owen, Kartik Temburnikar, Lauren Coco, Stephanie Henriquez, Faye Hern, Chung Liu, Anika Shakil, Megan Neary

Keywords(s): Disease Indication, HIV, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

PrEP Application for Persons at Risk of HIV

Unmet NeedThere remains a need for new and improved initiatives to identify and successfully engage and retain those people who may be at high risk of HIV infection or are infected with HIV.Technical DetailsJHU researchers have designed a patient facing linkage, adherence and retention based application to support HIV prevention. The application serves...

Published: 5/9/2024 | Inventor(s): Jason Farley, Kelly Lowensen

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Physics, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

Glutamine Antagonists for the Treatment of Cognitive Deficits, including NeuroAIDs

Some glutamine antagonists have been shown to have anti-cancer activities in multiple preclinical and clinical studies. However the toxicity of the glutamine antagonists at doses necessary for their anticancer effects have hampered their clinical development. Herein we describe a completely novel use for the glutamine antagonists. Using a prototype...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, David Volsky, Kristen Hollinger, Michael Nedelcovych, Atsushi Kamiya

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Cognitive Impairment, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Monoclonal Antibodies Against Leukocyte Adhesion Receptor Beta-Chain, Methods of Producing These Antibodies and Use Therefore

Monoclonal Antibody for Treatment and Diagnosis of AIDSJHU REF: [C09214] Invention Novelty: This technology is a novel monoclonal antibody specific against an epitope that suppresses immune response mediated diseases such as AIDS. Value Proposition: Acquired immunodeficiency syndrome (AIDS) is a fatal, incurable disease characterized by profound...

Published: 5/9/2024 | Inventor(s): James Hildreth, Thomas August

Keywords(s): Antibodies, Discovery/Research Tools, Disease Indication, HIV/AIDS, Infectious Diseases, Monoclonal Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS

MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389

TITLE: MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389CASE NUMBER: C13554ABSTRACTJHU researchers made use of a chimeric Moloney murine leukemia virus (MMLV)-HIV-1 Gag in which the p17 matrix domain of HIV-1 was replaced with the p15 matrix and p12 domains from MMLV. Murine cells expressing this construct released significant amounts of VLPs. The construct...

Published: 5/9/2024 | Inventor(s): Robert Siliciano, Soon Boon Wong

Keywords(s): Cloning Reagents, Discovery/Research Tools, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Peptides, Plasmid, Recombinant Proteins, Research Reagent, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Development of a Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans

Technical Details: WHO report has stated that there are 39.5 million people currently HIV positive worldwide. Of these, 4.3 million have been infected in the year 2006 alone. AIDS death reached 2.9 million this year which is the highest ever reported in any year. There are 40,000 new AIDS cases a year in U.S. along. The anti-HIV compounds that are currently...

Published: 5/9/2024 | Inventor(s): Ru Chih Huang, Ibrahim Abd-Elazem

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Herpes Simplex Virus, Herpes Simplex Virus (HSV), HIV, HIV/AIDS, Infectious Diseases, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Herpes Simplex Virus, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses

C03712: LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses Technical Details: JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, designated LuSIV, contains a reporter...

Published: 5/9/2024 | Inventor(s): Jason Roos, James Hildreth, Maureen Maughan, Janice Clements

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, HIV, HIV/AIDS, Human Cell Lines, In Vitro Research Tool, Infectious Diseases, Large Animal Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

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