Search Results - infectious+diseases

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Transgenic Fungi that Kill Malaria Parasites in Mosquitoes

Invention novelty: This material is a transgenic fungus which targets the sporozoites that cause malaria in the salivary glands of mosquitoes. The fungus is taken up by direct contact with the mosquito and inhibits Plasmodium development. Value Proposition: Unmodified, Metarhizium anisopliae kills mosquitoes slowly. If mosquitoes are infected by the...

Published: 5/2/2024 | Inventor(s): Raymond St. Leger, Angray Kang, Weiguo Fang, Marcelo Jacobs-Lorena

Keywords(s): Biologics, Disease Indication, Disease Management System, Healthcare Management, Infectious Diseases, Malaria, Operations Management, Parasitic Infections, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections

Antiviral Azide Containing Compounds

Unmet Need: Viral infections in humans, animals, plants and insects lead to many societal burdens including disease and agricultural loss. Most anti-viral treatment strategies to date are limited in scope to the virus of interest and often result in drug resistance, incomplete efficacy, and/or toxicity. Costs for viral specific targets can be massive...

Published: 5/2/2024 | Inventor(s): Upinder Singh, Scott Grecian, Brian Agnew, David Graham

Keywords(s): Antagonists/Inhibitors, Disease Indication, Drug Delivery Mechanism, Infectious Diseases, Oral Administration, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/2/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 5/2/2024 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Antigens Derived from Biofilm-like Microcolony Persister Form of Borrelia burgdorferi Improve Serodiagnosis of Lyme Disease

Unmet NeedLyme disease is one of many tick-transmitted diseases. Further investigation has revealed that Lyme disease is caused by the bacterium Borrelia burgdoferi. These bacteria transmit to humans via an infected deer tick and has affected over 25,000 Americans in the United States in 2002. Currently there are estimated to be 300,000 cases a year...

Published: 5/2/2024 | Inventor(s): Ying Zhang

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics (Old), Infectious Diseases, Lyme Disease

Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 5/2/2024 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/3/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Multi-epitope Fusion Antigen Vaccine for ETEC

Unmet Need: Enterotoxigenic Escherichia coli (ETEC) is the leading cause of diarrheal diseases worldwide but to date no effective vaccine exists due to the heterogeneity in ETEC strains. There is a need for a vaccine that elicits a broad yet productive immune response against multiple ETEC antigens to provide protection. Technical Details: Researchers...

Published: 5/2/2024 | Inventor(s): Weiping Zhang, David Sack

Keywords(s): Biologics, Disease Indication, Drug Delivery Mechanism, Immunotherapy, Infectious Diseases, Oral Administration, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 5/2/2024 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Polymer of Prodrug Methods for Sustained Release of Antivirals for Treatment or Prevention of HIV

Unmet Need:Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are amongst the most serious and challenging health problems in the world. There are nearly 37 million people worldwide living with HIV/AIDS and approximately 1 million AIDS-related deaths have occurred in 2017 alone - about 5,000 new infections per...

Published: 5/2/2024 | Inventor(s): Caren Freel Meyers, Steven Rannard, Andrew Owen, Kartik Temburnikar, Lauren Coco, Stephanie Henriquez, Faye Hern, Chung Liu, Anika Shakil, Megan Neary

Keywords(s): Disease Indication, HIV, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

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