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Transgenic Fungi that Kill Malaria Parasites in Mosquitoes

Invention novelty: This material is a transgenic fungus which targets the sporozoites that cause malaria in the salivary glands of mosquitoes. The fungus is taken up by direct contact with the mosquito and inhibits Plasmodium development. Value Proposition: Unmodified, Metarhizium anisopliae kills mosquitoes slowly. If mosquitoes are infected by the...

Published: 5/2/2024 | Inventor(s): Raymond St. Leger, Angray Kang, Weiguo Fang, Marcelo Jacobs-Lorena

Keywords(s): Biologics, Disease Indication, Disease Management System, Healthcare Management, Infectious Diseases, Malaria, Operations Management, Parasitic Infections, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections

RiBns for Rhomboid Proteases

This invention describes a method for creating novel, inhibitors of desired bacterial rhomboid proteases (RhP), and applies this method to produce potent antibiotics. The value proposition is very high providing a means of identifying and creating novel, specific bacterial Rhp inhibitors (antibiotics) with a novel mechanism of action to prevent/overcome...

Published: 5/2/2024 | Inventor(s): Sinisa Urban, Shiv Gandhi, Sangwoo Cho

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Biologics, Disease Indication, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules

Chromobacterium Csp_P as a versatile anti-malaria and anti-dengue mosquito-based transmission blocking agent

Unmet Need: Treatment and preventative measures against vector-borne diseases remain underdeveloped. With increasing resistance against drugs and insecticides, and a general lack of vaccines, there is an urgent need for disease transmission blocking strategies. Technical Details: Johns Hopkins researchers have developed a strategy using Chromobacterium...

Published: 5/2/2024 | Inventor(s): George Dimopoulos, Sarah Short, Jose Ramirez

Keywords(s): Biologics, Dengue Fever, Disease Indication, Infectious Diseases, Malaria, Parasitic Infections, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Dengue Fever, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Antibody-based Vectored Immunoprophylaxis Provides High-titer Plasmodium Falciparum Circumsporozoites Antibodies

Antibody-based immunoprophylaxis antimalarial therapyJHU REF: [C12545]Invention novelty: an improved antibody-based malarial therapyValue PropositionMalaria remains one of the world’s major causes of death, especially in Africa. Ninety percent of malaria mortalities occur in Africa, where it accounts for about one in five childhood deaths. WHO reported...

Published: 5/2/2024 | Inventor(s): Gary Ketner

Keywords(s): Antibodies, Biologics, Disease Indication, Infectious Diseases, Malaria, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria

A novel Malaria vaccine candidate

Novel Peptide Targeting for Malaria Therapeutic ApplicationsJHU REF: C12845Invention Novelty: Use of Plasmodium-derived peptides to reduce red blood cell invasion of Plasmodium parasites for the prevention and treatment of malariaValue Proposition: Malaria is an infectious disease caused by Plasmodium parasites. In order to induce fatal symptoms of...

Published: 5/2/2024 | Inventor(s): Jurgen Bosch, Daisy Colon Lopez, Ryan Smith

Keywords(s): Biologics, Disease Indication, Immunotherapy, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Small Molecule Malarial Aldolase-trap Enhancers and Glideosome Inhibitors

C12661: Novel Anti-Malarial Compounds and CompositionsNovelty: This technology provides new classes of anti-malarial compounds and a method to identify such compounds.Value Proposition: Nearly half the worlds population is at risk of acquiring malaria, which is caused by the Plasmodium family of protozoan parasites. Common drugs used to treat malaria...

Published: 5/2/2024 | Inventor(s): Sondra Nemetski, Timothy Cardozo, Jurgen Bosch

Keywords(s): Agonists/Promoters, Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Malaria, Novel, Parasitic Infections, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

An Inducible Reconstitution and Real-time Quantitative Kinetic System for the Analysis of Catalysis and Inhibition in Membranes

C12181: An assay to evaluate membrane-immersed enzyme kinetics in real time.Novelty: This technology is an inducible and real-time quantitative kinetic assay for the analysis of intra-membrane proteolysis.Value Proposition: Intra-membrane proteases can catalyze hydrolysis immersed within membranes. These enzymes are implicated in diseases such as Alzheimers...

Published: 5/2/2024 | Inventor(s): Seth Dickey, Rosanna Baker, Sinisa Urban

Keywords(s): Alzheimer's Disease, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Malaria, Parkinson's Disease, Tuberculosis (TB)

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Antimalarial Thioacetal Trioxanes in the Artemisinin Family

C11864: Novel Artemisinin Analog Antimalarial DrugsNovelty: The inventors have created several semisynthetic analogs of artemisinin with antimalarial properties.Value Proposition: In 2010, malaria affected over 216 million people, and while treatments for malaria exist, malaria parasites have grown resistant to several of the commonly used, quinoline-based...

Published: 5/2/2024 | Inventor(s): Alexander Jacobine, Rachel Slack, Jennifer Mazzone, Gary Posner

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Malaria, Novel, Parasitic Infections, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Monomeric Trioxane Amide Sulfur Compounds

C11486: Oral Single Dose Therapeutic for MalariaNovelty: The combination of a novel oral drug with Mefloquine administered as a single oral dose demonstrates anti-malarial activity.Value Proposition: Malaria is responsible for a million deaths each year and some treatments are not very effective, as the malarial parasite has developed resistance to...

Published: 5/2/2024 | Inventor(s): Rachel Slack, Gary Posner

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Hybridoma Clone PVALD 434-3 4A4.2E12 or PVALD 434-3 4A4.6B10 Producing Monoclonal Antibody to Pfalciparum Aldolase or Monoclonal Antibody Purified from same Hybridoma

C10647: Monoclonal Antibody to Pfalciparum Aldolase (Hybridoma Clone PVALD 434-3 4A4.2E12 or PVALD 434-3 4A4.6B10) Value Proposition: • This technology has an application to address a major patient need. • The ability to reliably diagnose malaria infections. • The monoclonal antibodies specific to aldolase. Technical Details: Malaria is...

Published: 5/2/2024 | Inventor(s): David Sullivan

Keywords(s): Antibodies, Basic Research Biomarker, Biomarker, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Hybridomas, In Vitro Diagnostics, In Vitro Research Tool, Infectious Diseases, Malaria, Monoclonal Antibodies, Parasitic Infections, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

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