Search Results - tuberculosis+(tb)

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Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 5/9/2024 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Clinical Decision Support MDR-TB Application

We have conceptualized and designed a clinical decision support application for MDR-TB. This application will assist clinicians (doctors, nurses, pharmacists) with the following types of information: a) standardized regimens; b) weight-based dosing; c) drug-drug interactions; d) side effect monitoring; e) symptom management; f) adherence to care.

Published: 5/9/2024 | Inventor(s): Jason Farley

Keywords(s): Bacterial Infections, Clinical Workflow Management System, Clinical Workflow Management Tools, Disease Indication, Healthcare Management, Infectious Diseases, Operations Management, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

The Johns Hopkins MDR-TB Training Program

Technical DetailsJohns Hopkins Researchers have developed a program that focuses on principles of adult learning theory to include didactic sessions, large group case studies, case-based small group exercises, educational materials and clinical support documents. Sessions include power point slides with speaker notes. Paper-based clinical decision...

Published: 5/9/2024 | Inventor(s): Jason Farley

Keywords(s): Bacterial Infections, Disease Indication, Education Management, Healthcare Education, Infectious Diseases, Operations Management, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Computers, Electronics & Software > Education Tech, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

TB-TLC = TB – Track/Link/Cure

We have designed a set of m-health applications that rapidly identify, link, and engage persons into TB care. Currently, reporting processes for TB are delayed and often require the healthcare worker to sift through multiple piles of paperwork. With this set of applications, a primary health care nurse or doctor can see the results in real-time directly...

Published: 5/9/2024 | Inventor(s): Jason Farley, Jane Mckenzie-White

Keywords(s): Bacterial Infections, Disease Indication, Disease Management System, Healthcare Management, Infectious Diseases, Operations Management, Tuberculosis, Tuberculosis (TB)

An Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis and Gram Positive Bacteria

TITLE: An Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis and Gram Positive BacteriaCASE NUMBER: C13966UNMET NEEDTuberculosis (TB) is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world. The number of cases of multidrug-resistant...

Published: 5/9/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Molecular Target of Mycobacterium Tuberculosis for Development of Drug and Vaccine

Susceptibility Target for TB TherapyJHU REF: C10895Invention novelty: This invention has identified a new target and a new way to kill the Mycobacterium tuberculosis pathogen.Value Proposition: Currently the mechanism by which M. tuberculosis maintains 3-3 cross-linkages in the peptidoglycan layer is not fully understood. Inventors at JHU and Universite...

Published: 5/9/2024 | Inventor(s): Jean-Luc Mainardi, Marie Lavollay, Michel Arthur, Radhika Gupta, Gyanu Lamichhane, William Bishai

Keywords(s): Bacterial Infections, Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

An Inducible Reconstitution and Real-time Quantitative Kinetic System for the Analysis of Catalysis and Inhibition in Membranes

C12181: An assay to evaluate membrane-immersed enzyme kinetics in real time.Novelty: This technology is an inducible and real-time quantitative kinetic assay for the analysis of intra-membrane proteolysis.Value Proposition: Intra-membrane proteases can catalyze hydrolysis immersed within membranes. These enzymes are implicated in diseases such as Alzheimers...

Published: 5/9/2024 | Inventor(s): Seth Dickey, Rosanna Baker, Sinisa Urban

Keywords(s): Alzheimer's Disease, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Malaria, Parkinson's Disease, Tuberculosis (TB)

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Guinea Pig-passaged H37Rv rel Mtb Mutant, rel Complement Strain, rel Tetracycline-inducible Knock-in Strain, rel Tetracycline-inducible Knock-down Strain

C11518: Transgenic rel Tubercle Bacilli for Anti-Tuberculosis Drug ScreeningNovelty: Transgenic guinea pig-passaged tubercle bacilli with modified rel expression levels useful for the identification of novel anti-tuberculosis therapeutics.Value Proposition: To date, tuberculosis (TB) infections are often unrecognized due to the ability of tubercle bacilli...

Published: 5/9/2024 | Inventor(s): Petros Karakousis

Keywords(s): Bacterial Infections, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Infectious Diseases, Knock Out Rabbit Model, Rabbit Model, Tuberculosis (TB)

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Auto-luminescent Mycobacterial Reporter Strains

C11128: Auto-luminescent Mycobacterial Reporter StrainsNovelty: This technology comprises novel engineered virulent strains of M. tuberculosis and M. ulcerans to produce light without requiring the addition of exogenous substrate.Value Proposition: The utility of existing bioluminescent mycobacterial strains in drug and vaccine development research...

Published: 5/9/2024 | Inventor(s): Eric Nuermberger, Jacques Grosset, Tianyu Zhang

Keywords(s): Bacterial Infections, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Infectious Diseases, Labels/Markers, Research Reagent, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

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