Search Results - jung+soo+suk

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Novel Bioreducible Polymer for Nucleic Acid Delivery to Eyes and Beyond

Unmet NeedInherited retinal diseases (IRDs) are a group of disorders with genetic and clinical heterogeneity and are the leading cause of vision loss. [1, 20] ] Collectively, IRDs have an estimated incidence of 1:2000. [1] Gene therapies targeting IRD, including FDA approved Luxturna, are injected directly into the retina to correct the underlying genetic...

Published: 5/10/2024 | Inventor(s): Jung Soo Suk, Gijung Kwak, Kai Zhang

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Ophthalmology

Nanocrystal-based Suspension Formulation of Nintedanib for Inhaled Treatment of Silicosis and other Fibrotic Lung Diseases

Value Proposition· Intranasal inhaled formulation of nintedanib (NTB) allows for more targeted dosing.· Minimizes risk of systemic adverse events in the lung.· Enhances drug retention in the lung for local treatment via inhalation.· Formulation allows for long-term storage and remote shipping.· Surface-stabilized with...

Published: 5/10/2024 | Inventor(s): Jung Soo Suk, Luisa Andrade da Silva, Patricia Rocco, Marcelo Morales

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Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Preparation and Use of a Conjugate of Anti-CD47 Antibody and Toll-like Receptor Agonist

Unmet NeedCancer treatment is an ongoing endeavor across the globe and there have been many milestones achieved recently in successfully treating cancer, such as immunotherapy and gene therapies. The current gold standards for the treatment of blood cancers include chemotherapy, radiation, stem cell transplants, surgery, and immunotherapy. Each of the...

Published: 5/10/2024 | Inventor(s): Jung Soo Suk, Seungwoo Chung, Yunxuan Xie

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Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Entirely GRAS Material-based Large Brain-Penetrating Nanoparticles for Widespread Therapeutic Distribution in Healthy and Tumor-bearing Brain Tissues

Unmet NeedGlioblastomas account for 45% of all brain cancers, and affect nearly 11,000 men, women and children every year. They are the most debilitating, complex, and treatment-resistant brain tumors. They can become widespread quickly and can grow in multiple areas at once making them difficult to remove completely using surgery or radiation therapy....

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Karina Negron, Justin Hanes

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Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

PEGylated Human Heavy Chain Ferritin Nanocages and Their Uses for Therapeutic and Diagnostic Delivery

Unmet Need:Localized delivery of chemotherapeutics to the lung via inhalation provides a straightforward method of directly targeting lung cancers. However, due to the presence of multiple delivery barriers, the effectiveness of the approach has been limited. Here, we disclose an invention of a novel inhalable drug delivery platform capable of...

Published: 5/9/2024 | Inventor(s): Justin Hanes, Jung Soo Suk, Xinglu Huang

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Lung Cancer, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Method to Improve Brain Penetration of Nanoparticles

Unmet Need / Invention Novelty: Drug delivery to the brain is hindered by the brain’s wide perivascular space and protein-dense extracellular matrix, which limits diffusion of drugs from site of administration into the brain parenchyma. Methods are needed to improve the penetration of drugs into the brain parenchyma. Technical Details: Johns Hopkins...

Published: 5/9/2024 | Inventor(s): Clark Zhang, Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Convection Enhanced Delivery (CED), Drug Delivery Mechanism, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Formulation Method and Use of Highly Stable Biodegradable Gene Vector Platforms Capable of Overcoming Various Biological Barriers

JHU researchers have formulated compact, colloidally stable gene carriers that have a dense surface coverage of hydrophilic and neutrally charged PEG. These gene vectors stably retain their physicochemical characteristics over at least a week in aqueous solution and are highly stable in physiological solutions. Moreover, they demonstrate the ability...

Published: 5/9/2024 | Inventor(s): Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Biologics, Drug Delivery Vehicle, Gene Therapy, Nucleic Acid, Plasmid/Vector, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Engineering Synthetic Brain Penetrating Gene Vectors

Unmet Need:Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Viral gene delivery, though relatively efficient, has been limited by immunogenicity, low packaging capacity and difficulties in manufacture and scale-up. Non-viral gene vectors offer an attractive alternate...

Published: 5/9/2024 | Inventor(s): Graeme Woodworth, Clark Zhang, Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Drug Delivery Vehicle Synthesis Method, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Engineering Synthetic Sputum-penetrating Gene Carriers

C11417: Synthetic Sputum-penetrating Gene CarriersNovelty: The technology provides novel compositions and methods to deliver gene therapy to cystic fibrosis (CF) patients.Value Proposition: CF is one of the most common genetic disorders. Currently, there are no aerosol gene delivery methods to efficiently penetrate the hyperviscoelestic sputum in the...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Justin Hanes

Keywords(s): Cystic Fibrosis (CF), Disease Indication, Drug Delivery Vehicle, Gene Therapy, Genetic Disorders, Nanoparticles, Polymers, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis