Search Results - clinical+and+disease+specializations+%3e+fibrosis

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Treatment of fibrosis-associated pathologies through downstream TGF-β pathway inhibition

Value PropositionInhibits downstream signaling pathway of TGF-β signaling, reducing pleiotropic and off-target effects.Selectively targets tissue specific calpains, increasing efficacy as compared to current TGF-β signaling pathway inhibitory methods.Applicable to several disease models with specific focus on epithelial-to-mesenchymal transition pathologies....

Published: 5/9/2024 | Inventor(s): David Kim, Harry Dietz

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Fibrosis Disorders, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Recombinant anti-PAD4 antibodies as a treatment for lung fibrosis

Value PropositionSelective monoclonal antibody therapy to treat lung fibrosis.Directly targets immune cells to promote a pro-inflammatory pathway that reduces fibrosis.High serum levels are associated with less severe lung disease, decreased fibrosis, and improved survival in a subset of rheumatoid arthritis patients.Broadly applicable to other diseases...

Published: 5/10/2024 | Inventor(s): Erika Darrah, Felipe Andrade, Kristen Demoruelle, Elizabeth Redente

Keywords(s):

Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications, Technology Classifications > Therapeutic Modalities

Nanocrystal-based Suspension Formulation of Nintedanib for Inhaled Treatment of Silicosis and other Fibrotic Lung Diseases

Value Proposition· Intranasal inhaled formulation of nintedanib (NTB) allows for more targeted dosing.· Minimizes risk of systemic adverse events in the lung.· Enhances drug retention in the lung for local treatment via inhalation.· Formulation allows for long-term storage and remote shipping.· Surface-stabilized with...

Published: 5/10/2024 | Inventor(s): Jung Soo Suk, Luisa Andrade da Silva, Patricia Rocco, Marcelo Morales

Keywords(s):

Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Polymer-Nucleic Acid Nanoparticles for Gene Editing

Inventors: Jordan J. Green, Stephany Yi Tzeng, Garry R. Cutting, Erin W. Kavanagh Unmet NeedCystic fibrosis (CF) is a progressive, genetic disease that affects the lungs, pancreas, and other organs. There are close to 40,000 children and adults living with cystic fibrosis in the United States (see CFF). In people with CF, mutations in the cystic fibrosis...

Published: 5/10/2024 | Inventor(s): Jordan Green, Stephany Tzeng, Garry Cutting, Erin Kavanagh

Keywords(s):

Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Gene Therapies

The Development of a Mini-scale Euglobulin Clot Lysis Assay

Unmet Need· A large proportion of patients with bleeding disorders fail to be diagnosed, and are classified as having bleeding of unknown cause due to a lack of sensitive assays for detecting abnormalities in fibrinolytic factors (Mehic et al. 2021). In addition, patients with young-onset or unprovoked venous thromboembolism, as well as those...

Published: 5/10/2024 | Inventor(s): Neil Goldenberg, Vera Ignjatovic, Steven Bruzek

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Pediatrics

Novel Gene Targets for Treatments Relating to Wound Healing, Immuno-oncology, and Fibrotic Disease

Unmet Need Hundreds of thousands of patients worldwide are affected by inflammatory diseases caused by a preexisting condition (inflammatory arthritis, psoriasis) or rejection of a foreign body (medical implant, open wounds). This is caused by the over/underexpression of certain phenotypes of macrophages within patients, yielding a disruption in homeostasis...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Christopher Cherry, Sven Sommerfeld

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets

Targeted Epigenetic Therapy against Distal Regulatory Element of TGFB2 Expression for Scleroderma and Fibrotic Disease

Unmet NeedScleroderma disorders comprise a heterogeneous group of conditions linked by the presence of thickened, sclerotic skin lesions. These conditions result in a poor quality of life and have a poor prognostic outcome. In particular, systemic sclerosis (SSc) has a 10 year mortality rate of approximately 30%. However, the pathogenic mechanisms of...

Published: 5/9/2024 | Inventor(s): Harry Dietz, Joseph Shin

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, Fibrosis Disorders, In Vitro Diagnostics, Prognostic Biomarker, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 5/9/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics