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Novel Therapeutic Drug for Multiple Sclerosis

INVENTION NOVELTY This molecule, through its action on a unique target that is different from current therapeutic treatments for MS, has both immunosuppressive and neuromodulatory properties that will better prevent the progression of MS and repair the neuronal damage caused by the immune cells in MS. Currently, there are no MS drugs in the market...

Published: 5/9/2024 | Inventor(s): Paul Kim, Michael Kornberg, Peter Calabresi, Solomon Snyder

Keywords(s): Chronic Inflammatory Diseases, CNS and Neurological Disorders, Disease Indication, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Targeting Endothelial Exocytosis in COVID-19

Unmet NeedCOVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of inflammation released by endothelial cells. Patients with serious infection are more likely to have COVID-19 associated coagulopathy than patients with mild infection, and those who die from COVID-19 are more likely to have...

Published: 5/10/2024 | Inventor(s): Charles Lowenstein

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Inflammation

Discovery of Novel Aryl Hydrocarbon Receptor Ligands and their Analogues for the Prevention and Treatment of Inflammatory Disorders

Unmet Need: Necrotizing enterocolitis (NEC) is the acute onset of inflammation in the gut of babies, and is the leading cause of premature infant mortality from gastrointestinal disease. The mortality of NEC is over 30%, and those infants who do survive suffer significant deficiency due to the effects of a damaged intestine, as well as profound cognitive...

Published: 5/10/2024 | Inventor(s): David Hackam, Peng Lu, Chhinder Sodhi, Peter Wipf, David Kornfilt

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis, Technology Classifications > Therapeutic Modalities

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 5/9/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

Endoscopic Accessory for Indocyanine Green (ICG)-Based Biliary Imaging during ERCP

Unmet NeedThe Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure is used to perform therapies such as retrieving obstructing gallstones, expanding tissue strictures, or placing a stent to relieve obstruction from malignancies. The procedure requires precision and a high degree of technical skill. For physicians to perform the procedure...

Published: 5/9/2024 | Inventor(s): Marc Chelala, Sritam Rout, Maria Torres, Kyle Cowdrick, Amir Soltanianzadeh, David Gullotti, Pankaj Pasricha, Nicholas Durr

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Pancreatic Disorders, Pancreatitis

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Inflammation, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Inflammation > Pancreatitis

Human immunoglobulin purified from NMO-IgG positive patient plasma

Purified Human IgG Antibodies from Positive NMO- IgG PatientJHU REF: [C12575]Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient. Value Proposition: NMO or Devic’s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific...

Published: 5/9/2024 | Inventor(s): Michael Levy

Keywords(s): Antibodies, Blood Samples, Buffer/Media Solution, Chronic Inflammatory Diseases, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Neuromyelitis Optica, Neuromyelitis optica (NMO), Optic Neuritis, Polyclonal Antibodies, Research Reagent, Translational Research Biomarker

MicroRNA Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation

TITLE: Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER: C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with...

Published: 5/9/2024 | Inventor(s): Stephen Meltzer, Alexandru Olaru

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Chronic Inflammatory Diseases, Cloning Reagents, Colorectal Cancer, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD), Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Therapeutic Matter, Therapeutics

CCL20 Reporter and Conditional Knockout Mice

TITLE CCL20 Reporter and Conditional Knockout MiceCASE NUMBERC13357ABSTRACTCCL20 a member of the macrophage inflammatory protein family and signal through the receptor CCR6, genomic location have been identified as a region important for bone quality. However, the role of CCL20 signaling in regulating...

Published: 5/9/2024 | Inventor(s): Scott Kominsky

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Inflammatory Disorders, Knock Out Mouse Model, Mouse Model, Skeletal Disorders

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Inflammation

Histamine Releasing Factor (HRF) Inducible Mice

C12573: Transgenic HFR Mouse Model for Asthma and Allergy Drug DiscoveryNovelty: A mouse strain harboring lung epithelial cell-targeted inducible HRF, permitting the site-specific, regulatable HRF over-expression to study its use as a drug target for asthma and allergies.Value Proposition: Asthma is a prevalent chronic lung disorder characterized by...

Published: 5/9/2024 | Inventor(s): Susan MacDonald

Keywords(s): Asthma, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Lung Disorders, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Respiratory Diseases > Asthma, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Respiratory Diseases

Functional magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences

C12282: Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are...

Published: 5/9/2024 | Inventor(s): Peter van Zijl, Craig Jones, Qin Qin, Jun Hua

Keywords(s): Cancers, CNS and Neurological Disorders, Diabetes, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Inflammatory Disorders, Magnetic Resonance Imaging (MRI), Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

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