Search Results - colorectal+cancer

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In vivo and in vitro Role of Lactosylceramide Synthase (LCS) in Angiogenesis and LCS (B1, 4GalT-V) as a Bio-marker for Human Colon Cancer

Description: C10539: Use of Biomarker for Colon Cancer Diagnosis Value Proposition: ADVANTAGES • Colon cancer biomarker is directly included in panels of biomarkers for use in needle biopsies of colon tissue for early detection and diagnosis. • Colon cancer is the second largest mortality after cardiovascular disease. 90% of colorectal cancers...

Published: 5/9/2024 | Inventor(s): Subroto Chatterjee

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Endoscope Localization Using Transmission Ultrasonography

Unmet NeedColonoscopies are one of the most frequently performed procedures in the United States, with over 14 million colonoscopies performed in the US each year. Colonoscopies can screen for colon cancer by identifying polyps, strictures, diverticulae, and other abnormalities. Accurate localization of the colonoscope tip is essential to pinpointing...

Published: 5/9/2024 | Inventor(s): James Taylor, Seth Goldstein

Keywords(s): Cancers, Colorectal Cancer, Disease Indication, Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Genetic Alterations Related to Anti-EGFR Therapeutic Response

Unmet Need:Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are monoclonal antibodies, which prevent epidermal growth factor receptor (EGFR) activation. Several studies have identified alterations in KRAS and other genes...

Published: 5/9/2024 | Inventor(s): Livio Trusolino, Andrea Bertotti, Victor Velculescu, Vilmos Adleff, Eniko Papp

Keywords(s): Biomarker, Cancers, Colorectal Cancer, Disease Indication, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

MicroRNA Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation

TITLE: Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER: C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with...

Published: 5/9/2024 | Inventor(s): Stephen Meltzer, Alexandru Olaru

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Chronic Inflammatory Diseases, Cloning Reagents, Colorectal Cancer, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD), Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Therapeutic Matter, Therapeutics

Biofilm Formation to Define Risk for Colon Cancer

Biofilm Detection to Define Risk for Colon CancerJHU REF: C12695Invention novelty: This technology is a diagnostic method for identifying people at risk for colon cancer employing analysis of biopsy specimens for biofilm formation. Value Proposition:Colorectal cancer is the third most commonly diagnosed cancer in the world. According to the American...

Published: 5/9/2024 | Inventor(s): Drew Pardoll, Elizabeth Wick, Christine Craig, Cynthia Sears

Keywords(s): Assay, Cancers, Clinical Diagnostics, Colorectal Cancer, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

USP9x-deficient HCT116 and DLD-1 Cells

USP9X-deficient cancer cell linesJHU REF: [C11655]Invention novelty: The technology consists of colorectal cancer cell lines possessing a knockout mutation in the USP9X gene with/without an additional deletion of p53.Value PropositionThe cell lines present an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study...

Published: 5/9/2024 | Inventor(s): Dennis Harris, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

An Endoscopic Device and Method to Retrieve Tetherless Microtools

C11519: Improved Colon Biopsy Devices: Tetherless Microtools and Magnetic Deployment/ Retrieval EndoscopeNovelty: The device and method is used to retrieve tissue with minimally invasive and collects large numbers of samples.Value Proposition: Current colon biopsy methods include collection of many, relatively large samples from multiple areas in the...

Published: 5/9/2024 | Inventor(s): David Gracias, Anthony Kalloo, Mouen Khashab, Florin Selaru

Keywords(s): Cancers, Clinical Diagnostics, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics, In Vitro Research Tool, Interventional and Surgical Systems, Pathology Tools, Sample Collection Method, Surgical Instruments

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Novel DNA hypermethylation diagnostic biomarkers for colorectal cancer

C11173: Tissue -derived Hypermethylated DNA Diagnostic Biomarkers for Colorectal CancerValue Proposition: DNA methylation is a mechanism where methyl groups are added to strands of DNA at CpG islands and is thought to modify gene expression. DNA hypermethylation is a common epigenetic abnormality found in cancers and is emerging as a promising class...

Published: 5/9/2024 | Inventor(s): Clement Boland, Ajay Goel, Stephen Meltzer, Yuriko Mori

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

AKT1 and AKT2 KO Cells

C10770: AKT1 and AKT2 KO CellsValue Proposition: Cell Lines AKT1-/- (D3A8G5) in HCT116 AKT1-/- (H1D1A12) in HCT116 AKT1-/-, AKT2-/- (HDK1-B2-F12-E5) in HCT116 AKT1-/-, AKT2-/- (HDK2-E1-B2-G3) in HCT116 AKT2-/- (A10A5C6) HCT116 in HCT116 AKT2-/- (C12B8B5) HCT116 in HCT116 AKT1-/- (D6D7A12) in DLD1 AKT1-/- (G10C3C5) in DLD1 AKT1-/-, AKT2-/- (DDK3-C2-G4-H2)...

Published: 5/9/2024 | Inventor(s): Victor Velculescu, Kajsa Ericson, Kenneth Kinzler, Nickolas Papadopoulos, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Lines, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines

ApoC1 KO Cells

C10769: ApoC1 KO Cells Technical Details: ApoC1 knockout inhuman colorectal cancer cell line HCT116.Looking for Partners: The cell lines described can be used in screens for novel molecules that target the ApoC1 pathway in human cancer cells to confirm the specificity of drugs discovered through other approaches. Such drugs can potentially be used...

Published: 5/9/2024 | Inventor(s): Victor Velculescu, Kenneth Kinzler, Yardena Samuels, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines

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