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Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 5/9/2024 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids

UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...

Published: 5/9/2024 | Inventor(s): Hongjun Song, Guo-li Ming, Mingxi Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian

Keywords(s): Bioreactor-based Manufacturing, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Research Instrument, Stem Cells

Category(s): Technology Classifications > Research Tools, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Industrial Manufacturing

Functional Fibers for Ex Vivo Expansion of Stem and Progenitor Cells

NeedUmbilical cord blood is a promising alternative source of hematopoietic stem/progenitor cells (HSPCs) for allogeneic and autologous hematopoietic stem cell transplantation for the treatment of a variety of hematological disorders and as supportive therapy for malignant diseases. However, the low number of HSPCs obtainable from a single donor restricts...

Published: 5/9/2024 | Inventor(s): Kam Leong, Kian-Ngiap Chua, Seeram Ramakrishna, Hai-Quan Mao

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools

Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)

The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.

Published: 5/9/2024 | Inventor(s): Linzhao Cheng

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Artificial Lymph Nodes for T cell Immunotherapy

Unmet Need Adoptive T cell transfer immunotherapy is a promising approach for treating a variety of cancer tumors. They involve the removal, culture, and expansion of resident T cells ex-vivo several thousand fold before reinfusion back into the body. However, a concern with current culturing methods is their inconsistency in developing and retaining...

Published: 5/9/2024 | Inventor(s): Jonathan Schneck, John Hickey, Hai-Quan Mao

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Immunotherapy, In Vitro Research Tool, Single, Therapeutic Matter, Therapeutic Method, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Immuno-Oncology

Generation of heart field-specific progenitor cells from pluripotent stem cells

Unmet Need:Heart disease, the number one killer, frequently occurs in a chamber-restricted fashion. While patient-derived pluripotent stem cells (iPSCs) offer unprecedented opportunities to treat and repair damaged hearts, iPSC-derived heart cells are highly heterogeneous, and it remains unknown if chamber-specific heart cells can be induced and isolated....

Published: 5/9/2024 | Inventor(s): Peter Andersen, Chulan Kwon

Keywords(s): Cardiovascular Diseases, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools

Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons

Unmet need This invention involves a novel method to immortalize Nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. More than half of all DRG neurons are unmyelinated axons that extend to the skin and have nociceptive properties. In many studies on peripheral...

Published: 5/9/2024 | Inventor(s): Weiran Chen, Ahmet Hoke

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cancer in Angiogenesis

Unmet NeedIn the United States alone, almost 8.5 million people suffer from peripheral artery disease (PAD). The market for PAD and Peripheral Vascular Disease (PVD) is expected to reach $378.53 million with a CAGR of 7.06% by 2024. Therapeutic angiogenesis are therapies aimed at growing new vessels into compromised tissue. Wound healing, PAD, and coronary...

Published: 5/9/2024 | Inventor(s): Andrew Schulick

Keywords(s): Biologics, Cardiovascular Diseases, Cell Model, Coronary Heart Disease, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Peripheral Artery Disease, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Whole cell, Wound Healing

Category(s): Technology Classifications > Therapeutic Modalities > Stem Cells, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Stem Cells

KA.1;KA.3 (human keratinocyte-iPSC)

Technical Details: Described are induced pluripotent stem cells (iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes. Associated Publication: PLoS One. 2012;7(8):e42838.

Published: 5/9/2024 | Inventor(s): Elias Zambidis

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Semaphorin 3D and Plexin D1 as New Therapeutic Targets for Pancreatic Cancer Treatment

Unmet Need: Most patients with pancreatic ductal adenocarcinoma (PDA) present with metastatic disease at the time of diagnosis or will recur with metastases after surgical treatment. Technology Overview: Semaphorin-plexin signaling mediates the migration of neuronal axons during development and of blood vessels during angiogenesis. The expression of...

Published: 5/9/2024 | Inventor(s): Lei Zheng

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mechanism-of-action Biomarker, Pancreatic Cancer, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

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