Search Results - jonathan+schneck

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Nanoparticles for Delivery of Immunoregulatory Materials to T Cells

Value Proposition:· This platform improves current methods for expansion of CD4+ T-cells, which could be used in adoptive transfer therapies.· Improves modulation, activation, and expansion of T cells over current methods used for CAR T-cell therapyTechnology Description· Researchers at Johns Hopkins have developed a nanoparticle-based...

Published: 5/10/2024 | Inventor(s): Jonathan Schneck, Ariel Isser

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Engineering Tech, Technology Classifications > Therapeutic Modalities

Artificial Lymph Nodes for T cell Immunotherapy

Unmet Need Adoptive T cell transfer immunotherapy is a promising approach for treating a variety of cancer tumors. They involve the removal, culture, and expansion of resident T cells ex-vivo several thousand fold before reinfusion back into the body. However, a concern with current culturing methods is their inconsistency in developing and retaining...

Published: 5/9/2024 | Inventor(s): Jonathan Schneck, John Hickey, Hai-Quan Mao

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Immunotherapy, In Vitro Research Tool, Single, Therapeutic Matter, Therapeutic Method, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Immuno-Oncology

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 5/9/2024 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

Immunoswitch Particles for the Conversion of Inhibitory Signals to Co-stimulatory Signals for Enhanced Immune-mediated Tumor Cell Killing

Unmet Need:One of the largest obstacles to overcome in cancer immunotherapy is the suppressive actions of the tumor microenvironment. Combination therapies that activate an immune response as well as block inhibitory pathways have potential in creating a prolonged and effective anti-tumor response. Technology Overview:Johns Hopkins researchers develop...

Published: 5/9/2024 | Inventor(s): Jonathan Schneck, Alyssa Kosmides Galaro

Keywords(s): Antibodies, Biologics, Cancers, Combination, Disease Indication, Drug Delivery Vehicle, Immunotherapy/ Immunotherapy, Nanoparticles, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Artificial Cells of Defined and Dynamic Size and Shape

Invention novelty: This invention is polymer based artificial cells that can be functionalized to induce an immune response or act as stem cells. Value PropositionAntibiotics are the most commonly used treatment for infectious diseases. Unfortunately, overuse and misuse of these compounds is fairly common, and results in the development of antibiotic...

Published: 5/9/2024 | Inventor(s): Joel Sunshine, Karlo Perica, Jonathan Schneck, Jordan Green

Keywords(s): Cancers, Cell Signaling, Cell Therapy, Discovery/Research Tools, Disease Indication, Melanoma, Molecular Switches/Receptors, Research Reagent, Single, Skin Cancer, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Melanoma