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Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 5/9/2024 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 5/9/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors

Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...

Published: 5/9/2024 | Inventor(s): Christopher Pavlos, Preeya Kapur Boppana, John Toscano

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Antigens for preparation of monoclonal antibodies

Unmet NeedMonoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular,...

Published: 5/9/2024 | Inventor(s): Gerald Hart

Keywords(s): Antigens, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Mouse Monoclonal Antibody 8A2

Unmet NeedMonoclonal Antibodies (mAB) serve an important role in cellular research and therapeutic applications. They are utilized to better understand various systems such as biochemical pathways, diseases, and mutations in the structures of invertebrates. There is a need to develop antibodies that specifically target areas within the biological landscape...

Published: 5/9/2024 | Inventor(s): Michael Matunis

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Olfactory Receptor Trafficking in Mammalian Cells

Invention novelty: The invention is a method and composition to ensure the cell surface expression of olfactory receptors (ORs) in heterologous systems.Value Proposition: Olfactory receptors are difficult to express in cell systems from which they are not derived. The ORs tend to remain intracellular in such systems, and use of these systems to identify...

Published: 5/9/2024 | Inventor(s): Jennifer Pluznick, Blythe Shepard, Niranjana Natarajan

Keywords(s): Discovery/Research Tools, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Engineered Tolerogenic Artificial Antigen-presenting Cells for Specific Expansion of Regulatory T Cells

Unmet NeedGlobal incidence of autoimmune disease is on the rise, and currently one in twelve Americans (including one in 9 women) suffer from autoimmune disease. Particularly, Type 1 Diabetes (T1D) represents a highly prevalent autoimmune disease, affecting over 20 million people. These diseases occur when the body’s immune system incorrectly attacks...

Published: 5/9/2024 | Inventor(s): Jordan Green, Jamie Spangler, Stephany Tzeng, Kelly Rhodes, Giorgio Raimondi, Marcos Iglesias Lozano, Jakub Tomala, Derek VanDyke, Randall Meyer

Keywords(s): Autoimmune Diseases, Biologics, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies

Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)

The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.

Published: 5/9/2024 | Inventor(s): Linzhao Cheng

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

A Novel mAb20-based In-cell ZnT8 Assay

Unmet Need: Prevalence of Type 2 Diabetes (T2D) continues to rapidly increase worldwide, contributing significant economic and global health burdens. There is an urgent need for the development of novel therapeutic strategies to treat T2D.Technical Details: Johns Hopkins researchers have identified a novel target to treat T2D and report here the development...

Published: 5/9/2024 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Analytical Method, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Proteomics/Immunoassays, Research Reagent, Target-based Screening Tool, Type II Diabetes

Category(s): Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

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