Search Results - monoclonal+antibodies

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Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 5/9/2024 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Highly Specific Monoclonal Antibodies used as Allosteric Inhibitors and Specific Biosensors of Human ZnT8

Unmet NeedType 2 diabetes (T2D) is a growing worldwide public health issue affecting over 500 million people while creating a $1 trillion economic burden on global healthcare economies. Many current and new therapeutics demonstrate varying degrees of effectiveness, but no single agent or combination thereof has been able to provide patients with lasting...

Published: 5/9/2024 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Antibodies, Biologics, Diabetes, Discovery/Research Tools, Disease Indication, Metabolic Disorders, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Type II Diabetes

Category(s): Technology Classifications > Research Tools > Research Antibodies, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Antibodies to Visual Pigment Proteins, Transcription Factor Sox17, and Multimerized Epitope Tags

Unmet Need:Canonical Wnt signaling is one of the major pathways involved in embryonic development and tissue regeneration. Recent studies suggest that canonical Wnt signaling is vital for brain angiogenesis and the acquisition of barrier properties by the microvasculature. There is a need in the field for the development of reagents that allow for the...

Published: 5/9/2024 | Inventor(s): Jeremy Nathans

Keywords(s): Antibodies, Discovery/Research Tools, Labels/Markers, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Research Antibodies

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

A Mouse Monoclonal Antibody Against Human LINE-1 ORF1p

Invention Novelty:Johns Hopkins researchers have developed a monoclonal antibody against the cancer-associated protein LINE-1 ORF1p. Technical Overview:There is great unmet need for a method of easily and broadly screening for cancer. Biomarkers, one of the major tools used in cancer screening, are usually specific for one cancer type, making testing...

Published: 5/9/2024 | Inventor(s): Kathleen Burns, Jef Boeke, Nemanja Rodic, Martin Taylor

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools

Monoclonal Antibodies Against the Barth Syndrome Gene Product, TAZ1, for Research and Diagnostic Applications

TITLEMonoclonal Antibodies Against the Barth Syndrome Gene Product, TAZ1, for Research and Diagnostic ApplicationsCASE NUMBERC12086Unmet Need: Barth syndrome (BTHS) is an X-linked disease characterized by cardiac and skeletal myopathies, delayed growth until puberty, and cyclic neutropenia; if undiagnosed, affected boys have only a 30% chance of survival...

Published: 5/9/2024 | Inventor(s): Steven Claypool

Keywords(s): Antibodies, Barth Syndrome, Barth Syndrome (BTHS), Barth syndrome (BTHS), Discovery/Research Tools, Disease Indication, Genetic Disorders, Monoclonal Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Barth Syndrome, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Monoclonal Antibodies Against Leukocyte Adhesion Receptor Beta-Chain, Methods of Producing These Antibodies and Use Therefore

Monoclonal Antibody for Treatment and Diagnosis of AIDSJHU REF: [C09214] Invention Novelty: This technology is a novel monoclonal antibody specific against an epitope that suppresses immune response mediated diseases such as AIDS. Value Proposition: Acquired immunodeficiency syndrome (AIDS) is a fatal, incurable disease characterized by profound...

Published: 5/9/2024 | Inventor(s): James Hildreth, Thomas August

Keywords(s): Antibodies, Discovery/Research Tools, Disease Indication, HIV/AIDS, Infectious Diseases, Monoclonal Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS

Development of a Novel Antibody to the Estrogen Receptor Beta (ERbeta)

Development of a novel antibody to the Estrogen Receptor beta (ER-beta)JHU REF: C13125Invention novelty: This tangible material is a genetically modified GnRH neuron-specific ER-beta knockout mouse model (GER-beta-KO) and a specific antisera for mouse ER-beta (mER-beta) that can be used to explore the cellular and physiological role of ER-beta.Value...

Published: 5/9/2024 | Inventor(s): Sally Radovick, Fredric Wondisford, Horacio Novaira, Andrew Wolfe

Keywords(s): Antibodies, Discovery/Research Tools, In Vivo Research Tool, Monoclonal Antibodies, Mouse Model, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

An Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer Therapy

TITLEAn Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer TherapyCASE NUMBERC11954ABSTRACTWe developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (SFU). It is well established that SFU works largely by inhibiting the enzyme thymidylate synthase (TS) in...

Published: 5/9/2024 | Inventor(s): Kalpeshkumar Patel, Scott Kern

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Pharmakodynamic Biomarker, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

RL12, RL1, RL13, RL2 Monoclonal Antibodies

TITLERL12, RL1, RL13, RL2 Monoclonal AntibodiesCASE NUMBERC03099ABSTRACTRL1, mouse monoclonal IgM that recognizes a group of eight O-linked glycoproteins of the nuclear pore complex, is a specific marker for the nuclear pore complex in species from yeast to humans; RL2, mouse monoclonal antibody that recognizes O-linked N-acetylglucosamine on a large...

Published: 5/9/2024 | Inventor(s): Larry Gerace

Keywords(s): Antibodies, Basic Research Biomarker, Biologics, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Monoclonal Antibodies, Mouse Model, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

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