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Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 5/9/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors

Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...

Published: 5/9/2024 | Inventor(s): Christopher Pavlos, Preeya Kapur Boppana, John Toscano

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Antigens for preparation of monoclonal antibodies

Unmet NeedMonoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular,...

Published: 5/9/2024 | Inventor(s): Gerald Hart

Keywords(s): Antigens, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Growth and Site-specific Organization of Micro-scale Bimolecular Devices on Living Mammalian Cells

Unmet Need: One aspect of a cell’s function is its ability to form organized structures both within the cell and with its immediate surrounding environment. On cell surfaces, these nanostructures can serve as scaffolds or operate functionally to aid in cellular fate decisions, signal amplification and cellular cross-talk. There is a need to understand...

Published: 5/10/2024 | Inventor(s): Rebecca Schulman, Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul Majeed Mohammed, Sean Sun, Takanari Inoue

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Vibrio Mutants that Convert Chitin Containing Waste Products to N-Acetylglucosamine

Unmet NeedAbout 1011 metric tons of chitin are produced annually in the ocean waters, and chitin is one of the most abundant organic substances in nature. It is a polymer composed of Nacetylglueosamine (GlcNAc) and glucosamine (GIcN) residues. These substances are considered to be valuable as supplements in the treatment of connective tissue diseases...

Published: 5/9/2024 | Inventor(s): Donald Comb, Xibing Li, Saul Roseman

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Antibodies to Visual Pigment Proteins, Transcription Factor Sox17, and Multimerized Epitope Tags

Unmet Need:Canonical Wnt signaling is one of the major pathways involved in embryonic development and tissue regeneration. Recent studies suggest that canonical Wnt signaling is vital for brain angiogenesis and the acquisition of barrier properties by the microvasculature. There is a need in the field for the development of reagents that allow for the...

Published: 5/9/2024 | Inventor(s): Jeremy Nathans

Keywords(s): Antibodies, Discovery/Research Tools, Labels/Markers, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Research Antibodies

14-3-3 Mediates a p53-Induced G2 Arrest

C03338: 14-3-3 Mediates a p53-Induced G2 Arrest Technical Details: Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Through a quantitative...

Published: 5/9/2024 | Inventor(s): Heiko Hermeking, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Cell Lines, Cell Signaling, Discovery/Research Tools, Disease Indication, Gene Therapy, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Pharmakodynamic Biomarker, Research Reagent, Single, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

An N-terminal Signal Peptide Increases Total Expression and Enhances Surface Trafficking of Olfactory Receptors

Unmet NeedThe present invention is based on the discovery of an N-terminal tag sequence which aids in olfactory receptor trafficking. When expressed exogenously in mammalian cells, olfactory receptors (ORs) fail to traffic to the cell surface. This is a problem as receptor ligands cannot be assayed unless the receptor is present on the cell surface....

Published: 5/9/2024 | Inventor(s): Niranjana Natarajan, Blythe Shepard, Jennifer Pluznick

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

New fluorinated DREADD actuators and ligands suitable for PET imaging

Unmet NeedChemogenetics is defined as a method by which proteins are made to interact with small molecules, typically neurological molecules, as they have never been interacted with before. There is a powerful and versatile approach for remote and momentary manipulation of cellular activity called Designer Receptors Exclusively Activated by Designer...

Published: 5/9/2024 | Inventor(s): Andrew Horti, Martin Pomper, Michael Michaelides, Jordi Bonaventura, Feng Hu, Juan Luis Gomez, Marta Sanchez-Soto

Keywords(s): Biologics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Radioisotope Therapy, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

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