Search Results - martin+pomper

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Uses of TSPO-targeting Compounds for Evaluation of Injuries in the Peripheral Nervous System

Value Proposition:· Technology combines positron emission tomography (PET) with targeted imaging compounds for a first-in-class approach to peripheral nerve injury (PNI) evaluation and monitoring.· Provides a method for non-invasive evaluation of PNI status immediately post-injury and over the recovery timeline. · Implementation...

Published: 5/10/2024 | Inventor(s): Martin Pomper, Catherine Foss, Sami Tuffaha, William Padovano

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Inhibition of rip kinases for treating neurodegenerative disorders

Unmet NeedNeurodegenerative disorders are a heterogeneous group that includes Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementia, and Huntington’s disease. These disorders result from progressive degeneration of the structure, function, and network of neurons in the central nervous...

Published: 5/9/2024 | Inventor(s): Seulki Lee, Han Seok Ko, Ted Dawson, Martin Pomper, Donghoon Kim, Yumin Oh, Seung-Hwan Kwon, Yong Joo Park

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Neurodegenerative Diseases, Parkinson's Disease, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Myelin Protein Zero (MPZ)-targeting Compounds and Uses Thereof

Unmet NeedPeripheral nerve injuries require optimally timed intervention to maximize functional recovery and minimize permanent nerve death and negative impacts to quality of life. Current treatment plans rely primarily on monitoring for spontaneous healing or an indication that there must be surgical intervention, an approach that hinges on accurate...

Published: 5/10/2024 | Inventor(s): Martin Pomper, Catherine Foss, Sami Tuffaha, William Padovano, Bei Cheng

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Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

A Simplified and More Accessible Method for Production of 111In-XYIMSR for Patient Use

Unmet NeedEach year in the United States, ~82,000 patients are diagnosed with renal cell carcinoma (RCC), and there are ~15,000 RCC-related deaths (1). 75-85% of these cancers are subtyped as clear cell renal cell carcinoma (ccRCC) (2). ccRCC is characterized by overexpression of carbonic anhydrase IX (CAIX) (3). Researchers have previously developed...

Published: 5/10/2024 | Inventor(s): Martin Pomper, Babak Behnam Azad, Robert Dannals, Daniel Holt

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Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Diagnostic Imaging, Clinical and Disease Specializations > Oncology > Renal Cell Carcinoma

AI Based Disease Prognosis of Patients with Parkinson's Disease

Unmet NeedParkinson’s Disease affects over 6 million people globally, and is one of the fastest growing neurodegenerative diseases in prevalence, disability, and deaths (GBD 2016 Parkinson’s Disease Collaborators). Presently, Parkinson’s diagnosis and prognosis depend on monitoring a patient’s symptoms and occasional imaging of the affected region of...

Published: 5/10/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper

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Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics

AI-based Disease Detection from Raw SPECT and PET Data without Image Reconstruction

Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven RoweUnmet NeedParkinson’s disease (PD) is the second most common neurodegenerative disorder, with approximately 60,000 Americans diagnosed with it each year. It is a progressive nervous system disorder that affects movement, from small tremors to a loss of automatic movements. One of the tools...

Published: 5/10/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe

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Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics

AI Based Medical Image Generation

Unmet NeedAdvances in medical imaging has radically changed the practice of medicine in the last few decades. Recently, machine learning techniques have been shown to produce higher fidelity images in various modalities and to aid in diagnostics (Lundervold & Lundervold, 2019). Machine learning imaging research require large datasets to be trained...

Published: 5/10/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe, Wenyi Shao

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Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Imaging

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 5/9/2024 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

Ai-based Image Reconstruction for SPECT and PET

Unmet NeedSPECT and PET imaging are two modalities which are widely implemented for the diagnosis, research and management of many diseases. The quality of their images is depleted by noise and other factors, causing the images to suffer from low resolution and artifacts. In addition, current iterative reconstruction techniques are extremely time consuming....

Published: 5/10/2024 | Inventor(s): Yong Du, Wenyi Shao, Martin Pomper

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Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

ENGINEERED CELLS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) OR A MODIFIED FORM THEREOF AND RELATED METHODS

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Various treatment strategies, including surgery, radiation and chemotherapy, exist for prostate cancer but their success depends on the stage of the cancer at diagnosis. Novel...

Published: 5/9/2024 | Inventor(s): Martin Pomper, David Huss, Hyam Levitsky, Il Minn

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Large Animal Cell Lines, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies

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