Search Results - prognostic+biomarker

23 Results

Sort By:

Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 5/9/2024 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 5/9/2024 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

Global DNA Hypomethylation as Biomarker for Clinical Detection, Inflammation Severity, and Disease Progression in Gastric Cancer

C11444: Novel Biomarker for Diagnosis of Gastric CancerNovelty: The reported technology identifies a novel biomarker for clinical detection, inflammation severity, and disease progression in gastric cancer.Value Proposition: The technology outlined is a diagnostic technique to detect a biomarker known to play a major role in gastric carcinogenesis....

Published: 5/9/2024 | Inventor(s): David Sidransky, Rafael Guerrero-Preston

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Gastric Cancer, In Vitro Diagnostics, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Gastric Cancer

DNA Methylation Biomarkers of Post Partum Depression Risk

Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting postpartum depression (PPD) risk . Value Proposition: PPD occurs in approximately 10-15% of women and represents a serious health risk to both mothers and their offspring. Increased depression risk in pregnant women is not predicted by hormonal fluctuations. This...

Published: 5/9/2024 | Inventor(s): Zachary Kaminsky, Jennifer Payne, Todd Gould

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Post Partum Depression, Postpartum Depression, Prognostic Biomarker, Psychiatric Diseases

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Clinical and Disease Specializations > Psychiatry > Postpartum Depression

Genomic Drivers of Response to Immunotherapy

Unmet NeedTumor mutational burden (TMB) is a measurement of mutations carried by tumor cells and is but one emerging biomarker for some types of cancer, including non-small cell lung cancer. Currently, there is a lack of standardization for tumor mutational burden calculation and reporting. Different tests may report different measurements, and since...

Published: 5/9/2024 | Inventor(s): Valsamo Anagnostou, Victor Velculescu, Noushin Niknafs Kermani

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics (Old), Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Computers, Electronics & Software > Algorithms

Targeted Epigenetic Therapy against Distal Regulatory Element of TGFB2 Expression for Scleroderma and Fibrotic Disease

Unmet NeedScleroderma disorders comprise a heterogeneous group of conditions linked by the presence of thickened, sclerotic skin lesions. These conditions result in a poor quality of life and have a poor prognostic outcome. In particular, systemic sclerosis (SSc) has a 10 year mortality rate of approximately 30%. However, the pathogenic mechanisms of...

Published: 5/9/2024 | Inventor(s): Harry Dietz, Joseph Shin

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, Fibrosis Disorders, In Vitro Diagnostics, Prognostic Biomarker, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Angiotensin Type 1 Receptor Autoantibody in Wound Healing

Unmet Need:Chronic wounds are among the most common, painful, debilitating and costly conditions in diabetics and in older adults, and are an important portal for bacterial infections that often lead to amputations, sepsis and mortality. In diabetic and aging skin, chronic inflammation commonly accompanies poor wound healing and increases the risk for...

Published: 5/9/2024 | Inventor(s): Peter Abadir, Jeremy Walston, Alka Jain, Neal Fedarko

Keywords(s): Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prognostic Biomarker, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Method to Determine Risk of Developing PTSD after Stressful Events

Unmet Need:Post-traumatic stress disorder (PTSD) is recognized by the Department of Defense, the Department of Veterans Affairs, and the National Institute of Mental Health as a major medical issue for both deployed and returning U.S. troops. PTSD rates in military personnel following deployment range from 5 to 15% (Sundin et al, 2010; Reijnen et al,...

Published: 5/9/2024 | Inventor(s): Zachary Kaminsky, Marco Boks

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Post-Traumatic Stress Disorder, Post-Traumatic Stress Disorder (PTSD), Prognostic Biomarker, Psychiatric Diseases

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Post-Traumatic Stress Disorder, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

Prognostic Markers in Pancreatic Cancer

TITLE: GENOMIC ALTERATIONS IN THE TUMOR AND CIRCULATION OF PANCREATIC CANCER PATIENTSCASE NUMBER: C13433UNMET NEEDSeveral genetic alterations have been identified in pancreatic cancers, including those in certain tumor suppressor genes and in oncogene. Although the discoveries of these genes and their pathways have provided important insights into...

Published: 5/9/2024 | Inventor(s): Victor Velculescu, Mark Sausen, Vilmos Adleff, Jillian Phallen

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pancreatic Cancer, Prognostic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Glioblastoma Biomarker for Improved Survival Prediction

TITLE: Glioblastoma Biomarker for Improved Survival PredictionCASE NUMBER: C13155UNMET NEEDGlioblastoma GBM), the most common primary brain tumor, has few available therapies providing significant improvement in survival. The median survival of patients after treatment is ~15 months, with only 3-5% surviving longer than 3 years. However, survival varies...

Published: 5/9/2024 | Inventor(s): Patrick Ha, Michael Lim, Chetan Bettegowda, Taeyoung Hwang, Chul-Kee Park, Dimitrios Mathios

Keywords(s): Biomarker, Brain Cancer, Breast Cancer, Cancers, Cervical Cancer, Clinical Diagnostics, Disease Indication, Glioma, In Vitro Diagnostics, Lung Cancer, Prognostic Biomarker

1 2 3