Search Results - jeremy+walston

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Selective Targeting of a Novel Protective Anti-inflammatory Receptor in Human Mitochondria and its Role in Preserving Mitochondrial Functions

Unmet NeedAccording to WHO, over one billion people worldwide are living with elevated blood pressure which may lead to a range of adverse health conditions that cause ~1,100 deaths per day. Many current high blood pressure therapies focus on angiotensin receptor blocking drugs. Unfortunately, adverse events (e.g., renal dysfunction, hyperkalemia, and...

Published: 5/9/2024 | Inventor(s): Andrew Cheetham, Peter Abadir, Jeremy Walston, Honggang Cui

Keywords(s): Antagonists/Inhibitors, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Supramolecular Hydrogels Containing Angiotensin Receptor Blockers for Targeted Treatment of Diabetic Wounds

Unmet Need: Dysregulation in the renin-angiotensin system (RAS) has been increasingly implicated in abnormal diabetic wound healing. The effect of angiotensin receptor blockers in a wounded subject can be harmful during the early stages of wound healing; however, use of angiotensin receptor blockers during the later proliferative and remodeling stages...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Jeremy Walston, Peter Abadir, Ran Lin

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Comprehensive Phenotyping Reveals Robust Determination to Cellular Biological Age

Technology OverviewJHU researchers have developed a platform to determine the cellular biological age of individuals based on quantifiable functional outputs of their cells. Using a comprehensive approach, of high-throughput single cell technologies to measure biochemical and biophysical properties of cells, we have further developed a generalized linear...

Published: 5/9/2024 | Inventor(s): Jude Phillip, Denis Wirtz, Pei-Hsun Wu, Jeremy Walston

Keywords(s): Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, In Vitro Research Tool, Physics, Research Instrument

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Angiotensin Type 1 Receptor Autoantibody in Wound Healing

Unmet Need:Chronic wounds are among the most common, painful, debilitating and costly conditions in diabetics and in older adults, and are an important portal for bacterial infections that often lead to amputations, sepsis and mortality. In diabetic and aging skin, chronic inflammation commonly accompanies poor wound healing and increases the risk for...

Published: 5/9/2024 | Inventor(s): Peter Abadir, Jeremy Walston, Alka Jain, Neal Fedarko

Keywords(s): Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prognostic Biomarker, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Presence of a Novel Protective Anti-inflammatory Receptor in Human Mitochondria and Its Role in Preserving Mitochondrial Functions

C10816: Wound Healing Therapeutic Based on Protective Anti-inflammatory Receptor Value Proposition: JHU scientists have recently determined that mitochondria contain functional Angiotensin (AT) receptors which are anti-inflammatory and potential targets for agents that protect and preserve mitochondrial function, possibly through anti-inflammatory properties...

Published: 5/9/2024 | Inventor(s): Peter Abadir, Jeremy Walston

Keywords(s): Biomarker, Disease Indication, Mechanism-of-action Biomarker, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Wound Healing

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Wound Healing

Frailty Screening Tools

C10021: Standardized Frailty Evaluation Tool for Elderly PatientsNovelty: Easy to use and implement frailty assessment tool for improved and standardized medical evaluation of the elderly patients.Value Proposition: Current standard medical indications do not take account the frailty of older patient, resulting in imprecise assessment of the risk involved...

Published: 5/9/2024 | Inventor(s): Jeremy Walston

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Measurement Tool

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Copyright