Search Results - honggang+cui

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Peptide-Based Antifouling Membrane Filtration Systems for Continuous Protein Harvesting

Unmet NeedCell and cell-derived therapies, including protein and antibodies, are being developed as a new and promising class of medicine. These kinds of therapeutics require a nuanced and precise manufacturing process, including bioreactors and filtration systems that can reliably obtain large quantities of the desired product consistently [8, 9]....

Published: 5/10/2024 | Inventor(s): Honggang Cui, Boran Sun, Michael Betenbaugh, David Stern

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Selective Targeting of a Novel Protective Anti-inflammatory Receptor in Human Mitochondria and its Role in Preserving Mitochondrial Functions

Unmet NeedAccording to WHO, over one billion people worldwide are living with elevated blood pressure which may lead to a range of adverse health conditions that cause ~1,100 deaths per day. Many current high blood pressure therapies focus on angiotensin receptor blocking drugs. Unfortunately, adverse events (e.g., renal dysfunction, hyperkalemia, and...

Published: 5/9/2024 | Inventor(s): Andrew Cheetham, Peter Abadir, Jeremy Walston, Honggang Cui

Keywords(s): Antagonists/Inhibitors, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 5/10/2024 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

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Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers

Peptide for the Prevention and Treatment of Coronavirus Infection

Value Proposition· Peptide-based supramolecular filament that attenuates SARS-CoV virus infectivity in vivo· Leverages ACE2 enzyme-substrate docking activity· Enables therapeutic protein delivery in repairable aerosolsUnmet Need· Respiratory illnesses, including tuberculosis, influenza, and COVID-19, pose a significant worldwide...

Published: 5/10/2024 | Inventor(s): Honggang Cui, Hongpeng Jia, Caleb Anderson

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Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Inhalable Supramolecular Therapeutics to Treat Lung Diseases

Unmet NeedThe current global market for respiratory drugs is expected to increase from $30.9 billion in 2016 to $41.3 billion in 2023. While many aerosol therapeutics are used to treat lung diseases such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis, administration of drugs selectively to the lungs remains challenging. The nature...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Caleb Anderson

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Lung Disorders, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Local Cancer Chemo-immunotherapy Elicit Regression of Tumors

Unmet NeedThe market size for cancer immunotherapy was worth $58.1 billion in 2018, and with a CAGR of 14.5%, it is likely to reach up to $126.9 billion by 2026. Cancer immunotherapy is an extremely interesting and attractive means of extending the lifespan of patients with certain cancers. However, only about 15% of patients with advanced-stage cancer...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Feihu Wang, Hao Su

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Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Immuno-Oncology

Approaches to Engineering Self-Assembling Peptide Filaments for Protein Binding and Purification

Unmet NeedPeptide amphiphiles (PA) are engineered biomaterials that can self-assemble into nanostructures with specific functions, such as binding to biomarkers for a variety of diseases, binding to specific proteins for purification purposes, or for binding to location specific regions for locally administering drugs. Most PAs currently synthesized...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Reagent

Category(s): Technology Classifications > Research Tools

Supramolecular Hydrogels Containing Angiotensin Receptor Blockers for Targeted Treatment of Diabetic Wounds

Unmet Need: Dysregulation in the renin-angiotensin system (RAS) has been increasingly implicated in abnormal diabetic wound healing. The effect of angiotensin receptor blockers in a wounded subject can be harmful during the early stages of wound healing; however, use of angiotensin receptor blockers during the later proliferative and remodeling stages...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Jeremy Walston, Peter Abadir, Ran Lin

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Self-assembling CPT-drug Amphiphiles for Cancer Treatment

Unmet need: DNA topoisomerases have become a widely exploited chemotherapeutic drug target for the treatment of advanced cancer. Multiple classes of topoisomerase inhibitors have been marketed including camptothecin (CPT) derivatives. However, while these analogues are less toxic than CPT, they are have reduced efficacy due to their prodrug formulation,...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Hao Su, Feihu Wang

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Peptides/Prodrugs, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology

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