Search Results - clinical+and+disease+specializations+%3e+respiratory+diseases

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Adoptive Transfer of CD49a TRM Stop and Reverse Lung Fibrosis

Value Proposition:· Cellular therapy for the treatment of lung fibrosis with potential to stop and reverse underlying disease pathology.· Improved efficacy and accessibility compared to status-quo therapies.· Potential autologous therapy, as peripheral T cells can be used to induce this tissue resident memory subset.Technology Description....

Published: 5/10/2024 | Inventor(s): Maureen Horton, Jonathan Powell, Samuel Collins, Yee Chan Li

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Cell Therapies

Peptide for the Prevention and Treatment of Coronavirus Infection

Value Proposition· Peptide-based supramolecular filament that attenuates SARS-CoV virus infectivity in vivo· Leverages ACE2 enzyme-substrate docking activity· Enables therapeutic protein delivery in repairable aerosolsUnmet Need· Respiratory illnesses, including tuberculosis, influenza, and COVID-19, pose a significant worldwide...

Published: 5/10/2024 | Inventor(s): Honggang Cui, Hongpeng Jia, Caleb Anderson

Keywords(s):

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Engineered Extracellular Vehicles as a selective drug delivery platform

Value Proposition:· Engineered extracellular vesicles with enhanced uptake and reduced immunogenicity · Improved EV-based drug delivery platform Technology DescriptionResearchers at Johns Hopkins have identified endogenous proteins that can be engineered to assist in extracellular vesicle and/or nanoparticle therapeutics through increased...

Published: 5/10/2024 | Inventor(s): Kenneth Witwer, Zach Troyer

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Self-powered, Acoustic Impedance-matched Transducer

Unmet NeedAcoustic energy (i.e., sound energy) is an energy disturbance that can pass through materials in the form of waves.1. Examples of sound energy can be speech, music, or environmental noise. The wave vibrations from sound energy contain a wealth of information about their source and surroundings. For example, body sounds can provide health and...

Published: 5/10/2024 | Inventor(s): James West, Valerie Rennoll, Adebayo Eisape, Ian McLane, Mounya Elhilali

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Respiratory Diseases

Aerosol Biosensor for Preclinical Detection of Coronavirus

Unmet NeedCurrent testing methods for COVID-19 can provide results in as little as 24 hours and as long as 10 days, depending on the testing method and the location. Self-quarantining of infected individuals is vital when they are spreading the virus, and these tests are necessary to monitor the spread of the disease, in order to emphasize community...

Published: 5/10/2024 | Inventor(s): Chao Wang, Hongpeng Jia, Mukund Madhav Goyal

Keywords(s):

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Diagnostics

Detection of ACE2 autoantibodies as markers of severity in COVID-10 patient

Unmet Need / Invention Novelty: SARS-CoV-2 infection can result in severe disease in a subset of infected patients. However, the mechanism underlying severe infection is unknown, hindering patient stratification. There is an unmet need to quickly diagnose and detect markers of severe COVID-19 infection. Technical Details: Researchers at Johns Hopkins...

Published: 5/10/2024 | Inventor(s): Antony Rosen, Livia Casciola-Rosen

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases

Inhalable Supramolecular Therapeutics to Treat Lung Diseases

Unmet NeedThe current global market for respiratory drugs is expected to increase from $30.9 billion in 2016 to $41.3 billion in 2023. While many aerosol therapeutics are used to treat lung diseases such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis, administration of drugs selectively to the lungs remains challenging. The nature...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Caleb Anderson

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Lung Disorders, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Leptin Prevents Opiate-induced Respiratory Depression

Description:Unmet Need The opioid epidemic continues to be a public health crisis, with about 130 Americans dying every day from an opioid overdose. Opiate-mediated respiratory suppression (ORS) is the primary cause of opiate-associated deaths, and obesity greatly increases opiate-related mortality. Obesity also contributes to obstructive sleep apnea...

Published: 5/9/2024 | Inventor(s): Vsevolod Polotsky, David Mendelowitz, Carla Freire

Keywords(s): Biologics, Combination, Drug Delivery Mechanism, Intranasal Administration, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Respiratory Diseases

Quality of Life in Mechanically Ventilated Patients

Unmet NeedPatients with respiratory failures are increasingly undergoing mechanical ventilation ("MV"). MV drains hospital resources, prolongs hospital stays, and has cost U.S. hospitals more than $16 billion.As MV renders most patients non-verbal, it is crucial to be able to assess their quality of life and well-being while they are in a...

Published: 5/9/2024 | Inventor(s): Vinciya Pandian

Keywords(s): Clinical Workflow Management Tools, Healthcare Management, Information Collection Form, Operations Management

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics

Protection of lung cells from cigarette smoke, a primary insult causing chronic obstructive pulmonary disease (COPD) and other lung diseases, and ability to increase airway surface hydration and maintain ciliary function.

Unmet NeedChronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death globally by 2030, with cigarette smoke being a major cause. Despite the prevalence of COPD there has been very little progress in developing therapeutic strategy in past 20 years. Thus, mechanistic studies for therapeutic targets for treating...

Published: 5/9/2024 | Inventor(s): Douglas Robinson, Corrine Kliment, Venkataramana Sidhaye, Jennifer Nguyen

Keywords(s): Chronic Obstructive Pulmonary Disorder, Chronic Obstructive Pulmonary Disorder (COPD), Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Respiratory Diseases > Chronic Obstructive Pulmonary Disorder

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