Search Results - jonathan+powell

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Adoptive Transfer of CD49a TRM Stop and Reverse Lung Fibrosis

Value Proposition:· Cellular therapy for the treatment of lung fibrosis with potential to stop and reverse underlying disease pathology.· Improved efficacy and accessibility compared to status-quo therapies.· Potential autologous therapy, as peripheral T cells can be used to induce this tissue resident memory subset.Technology Description....

Published: 5/10/2024 | Inventor(s): Maureen Horton, Jonathan Powell, Samuel Collins, Yee Chan Li

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Cell Therapies

Preventing Acute Kidney Injury Using JHU083

Unmet Need: It is estimated that 13.3 million people worldwide are affected by acute kidney injury (AKI) (see Bjornstad et. al). AKI is an especially prevalent condition in kidney transplant recipients, with one study showing that 35% of recipients had at least one episode of AKI (see Palmisiano et. al). These injury events lead to worsening kidney...

Published: 5/10/2024 | Inventor(s): Hamid Rabb, Barbara Slusher, Jonathan Powell, Kyungho Lee, Elizabeth Thompson, Sanjeev Noel, Sepideh Gharaie

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Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Nephrology

New Method of mTOR Regulation by TSC2 Modification

Unmet NeedImmunotherapies that boost T cell responses have demonstrated therapeutic efficacy in numerous cancers. To improve the efficacy and expand the clinical utility of immunotherapy, improved methods of stimulating T cell responses are needed. mTORC1 is a critical regulator of T cell activation, differentiation and function. While modulating mTORC1...

Published: 5/9/2024 | Inventor(s): David Kass, Mark Ranek, Kristen Kokkonen, Jonathan Powell, Chirag Patel

Keywords(s): Cancers, Cell Therapy/Gene Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities

Manipulation of Regulatory T Cell and DC Function by Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists

Unmet NeedThe recent breakthroughs in immuno-oncology have changed the way that researchers think about treating autoimmune diseases and cancer by modulating the immune system. Regulatory T cells (Treg) limit autoimmunity but also attenuate the potency of antitumor immunity. Enhancement of Treg function could treat autoimmune diseases while the inhibition...

Published: 5/9/2024 | Inventor(s): Drew Pardoll, Joseph Barbi, Fan Pan, Hong Yu, Ching-Tai Huang, Xiaoyu Pan, Charles Drake, Jonathan Powell

Keywords(s): Antibodies, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics

A Novel Approach to Enhance Specific Immunity by Constraining Antibodies on Nanoparticles

Antibodies have exquisite specificity for their antigen. Thus antibodies have great therapeutic potential in terms of selectively targeting receptors to either promote or inhibit receptor activity. Likewise, antibodies can target infected or tumor cells by recognizing their antigen on the cell of interest. However, the exquisite specificity imparted...

Published: 5/9/2024 | Inventor(s): Michael Edidin, Ying-Chun Lo, Jonathan Powell

Keywords(s): Antibodies, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Inhibition of SGK-1 as a Novel Means to Treat Autoimmune Disease and Enhance Anti-pathogen and Anti-tumor Immunity

C11550: Novel Target for Treatment of Autoimmune DiseasesNovelty: Inhibition of this novel target has the potential to treat autoimmune diseases, as well as enhancing immunity against pathogen infections and tumor formation.Value Proposition: Currently, most immunosuppressive therapies non-specifically inhibit the immune system and leave the body susceptible...

Published: 5/9/2024 | Inventor(s): Emily Heikamp, Jonathan Powell

Keywords(s): Autoimmune Diseases, Biomarker, Cancers, Disease Indication, Immunotherapy, Inflammatory Disorders, Mechanism-of-action Biomarker, Single, Target, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Immunology

Manipulation of the Transcription Factor Helios to Enhance or Down-modulate Regulatory T Cell Function

C10323: Modulation of Regulatory T cell (Treg) Function Value Proposition: • Up-regulate immune response • Down-regulate immune response • Treatment of cancer, infection, autoimmunity, and inflammationTechnical Details: Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. In some diseases, i.e....

Published: 5/9/2024 | Inventor(s): Jonathan Powell, Joseph Grosso, Edward Hipkiss, Drew Pardoll, Derese Getnet, Charles Drake

Keywords(s): Autoimmune Diseases, Biomarker, Cancers, Disease Indication, Inflammatory Disorders, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and Antagonists

C04897: Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and AntagonistsValue Proposition: • Therapeutic target for developing tolerance-inducing agents and tolerance-inhibiting agents for the treatment of autoimmune disease and cancer • Methods of treating an infection by enhancing the generation of antigen-specific...

Published: 5/9/2024 | Inventor(s): Paul Zarek, Charles Drake, Jonathan Powell

Keywords(s): Agonists/Promoters, Antagonists/Inhibitors, Autoimmune Diseases, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Inflammatory Disorders, Non-novel, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities