Search Results - hamid+rabb

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Preventing Acute Kidney Injury Using JHU083

Unmet Need: It is estimated that 13.3 million people worldwide are affected by acute kidney injury (AKI) (see Bjornstad et. al). AKI is an especially prevalent condition in kidney transplant recipients, with one study showing that 35% of recipients had at least one episode of AKI (see Palmisiano et. al). These injury events lead to worsening kidney...

Published: 5/10/2024 | Inventor(s): Hamid Rabb, Barbara Slusher, Jonathan Powell, Kyungho Lee, Elizabeth Thompson, Sanjeev Noel, Sepideh Gharaie

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Nephrology

Deletion of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice

Invention novelty: This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.Value Proposition:The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and...

Published: 5/9/2024 | Inventor(s): Samatha Bandapalle, Sanjeev Noel, Hamid Rabb

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool, Kidney Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Early Diagnostic Biomarker for Acute Kidney Injury

C04756: Early Diagnostic Biomarker for Acute Kidney InjuryNovelty: Novel, early stage biomarker for easy diagnostic of acute kidney injury (AKI), acute renal failure (ARF) renal ischemia reperfusion injury, and/or ischemic acute tubular necrosis.Value Proposition: ARF is a syndrome with high mortality and morbidity, for which there is no specific therapy...

Published: 5/9/2024 | Inventor(s): Hamid Rabb

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Diagnostic Tool, Disease Indication, Kidney Disorders, Kidney Failure

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology > Kidney Failure, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Nephrology > Renal Ischemia