Search Results - clinical+and+disease+specializations+%3e+nephrology

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Preventing Acute Kidney Injury Using JHU083

Unmet Need: It is estimated that 13.3 million people worldwide are affected by acute kidney injury (AKI) (see Bjornstad et. al). AKI is an especially prevalent condition in kidney transplant recipients, with one study showing that 35% of recipients had at least one episode of AKI (see Palmisiano et. al). These injury events lead to worsening kidney...

Published: 5/10/2024 | Inventor(s): Hamid Rabb, Barbara Slusher, Jonathan Powell, Kyungho Lee, Elizabeth Thompson, Sanjeev Noel, Sepideh Gharaie

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Nephrology

Device and Method to produce Dialysate

Unmet NeedAcute kidney injury is common among critically ill patients, and has an associated mortality rate of 30% to 70% [1]. Continuous veno-venous hemodialysis (CVVHD) is a treatment for acute kidney injury that uses diffusive clearance to remove toxins and solutes from the patient’s circulation. In CVVHD, dialysate, which is a nonsterile aqueous...

Published: 5/10/2024 | Inventor(s): Chirag Parikh, Derek Fine, Mohit Singhala, Ryan Bell, Brielle Cenci

Keywords(s):

Category(s): Clinical and Disease Specializations > Nephrology, Technology Classifications > Therapeutic Modalities

Photo-Assisted Vascular Access Guide

Unmet NeedApproximately 600,000 patients in the United States today are on hemodialysis. In order for long-term applicability of hemodialysis, either arteriovenous fistulas (AVF) or arteriovenous grafts (AVG) are utilized. AVFs utilize the patient’s own vein and AVGs are artificial conduits that allow long-term access to the patient’s blood flow and...

Published: 5/9/2024 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cancers, Disease Indication, Interventional and Surgical Systems, Kidney Disorders, Surgical Instruments, Surgical Tubing

Category(s): Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Surgical

Magnet Assisted Vascular Access Guide

Unmet NeedApproximately 600,000 patients in the United States today are on hemodialysis. In order for long-term applicability of hemodialysis, either arteriovenous fistulas (AVFs) or arteriovenous grafts (AVGs) are utilized. AVFs utilize the patient’s own vein while AVGs are artificial conduits that allow long term access to the patient’s blood flow...

Published: 5/9/2024 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cancers, Disease Indication, Interventional and Surgical Systems, Kidney Disorders, Surgical Instruments, Surgical Tubing

Category(s): Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Surgical

11C-PABA as a Novel Functional Renal Imaging Agent

Unmet Need: Assessing kidney function is often essential for clinical decision making for a variety of diseases including chronic kidney disorder (CKD). CKD affects more than 30 million Americans and millions of others are at an increased risk of developing it. The gold standard for measuring renal function for diagnosing/monitoring CKD and other disorders...

Published: 5/9/2024 | Inventor(s): Sanjay Jain, Alvaro Ordonez, Camilo Ruiz-Bedoya

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Kidney Disorders, Positron Emission Tomography (PET)

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Clinical and Disease Specializations > Nephrology

HeRS App (Hemorrhage Risk Stratification)

HeRS App: The app is a calculator for mobile phones, tablets, and other electronic devices such as computers. It allows the user to input patient: age, renal function, and size of stroke. It then provides an estimation of the probability of hemorrhagic transformation during a patients’ hospitalization. The HeRS score is a prospectively validated equation...

Published: 5/9/2024 | Inventor(s): Rafael Llinas, Elisabeth Marsh, Peter Dziedzic

Keywords(s): Clinical Diagnostics, CNS and Neurological Disorders, Computer and Network Systems, Computer Software, Diagnostic Tool, Disease Indication, Hemorrhage, Kidney Disorders, Measurement Tool, Stroke, Vascular Diseases

Deletion of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice

Invention novelty: This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.Value Proposition:The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and...

Published: 5/9/2024 | Inventor(s): Samatha Bandapalle, Sanjeev Noel, Hamid Rabb

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool, Kidney Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Early Diagnostic Biomarker for Acute Kidney Injury

C04756: Early Diagnostic Biomarker for Acute Kidney InjuryNovelty: Novel, early stage biomarker for easy diagnostic of acute kidney injury (AKI), acute renal failure (ARF) renal ischemia reperfusion injury, and/or ischemic acute tubular necrosis.Value Proposition: ARF is a syndrome with high mortality and morbidity, for which there is no specific therapy...

Published: 5/9/2024 | Inventor(s): Hamid Rabb

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Diagnostic Tool, Disease Indication, Kidney Disorders, Kidney Failure

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology > Kidney Failure, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Nephrology > Renal Ischemia