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PSMA Chimeric Antigen Receptor-Modified Proinflammatory Myeloid Cells

Unmet Need: Prostate cancer remains one of the leading causes of cancer-related death among men. Clinical translation of PSMA-CAR-T cell therapies under investigation is hindered by questions as to their tumor infiltration, efficacy, and durability. Immature myeloid cells deficient in the p50-subunit of NF-κB (p50-IMCs) enhance T cell activation. As...

Published: 5/17/2024 | Inventor(s): Alan Friedman

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

Adoptive Proinflammatory Myeloid Cell Therapy for Cancer

Unmet Need: Prostate cancer is one of the most commonly diagnosed cancers in the male population; roughly one out of ten men will be diagnosed at some point in their lives. Despite extending survival, androgen depravation therapy invariably leads to the development of lethal castration resistant prostate cancer. Similarly, pancreatic ductal carcinoma...

Published: 5/17/2024 | Inventor(s): Alan Friedman

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Oncology

Adoptive Transfer of CD49a TRM Stop and Reverse Lung Fibrosis

Value Proposition:· Cellular therapy for the treatment of lung fibrosis with potential to stop and reverse underlying disease pathology.· Improved efficacy and accessibility compared to status-quo therapies.· Potential autologous therapy, as peripheral T cells can be used to induce this tissue resident memory subset.Technology Description....

Published: 5/10/2024 | Inventor(s): Maureen Horton, Jonathan Powell, Samuel Collins, Yee Chan Li

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Cell Therapies

Conversion of retinal glia into neurons for cell replacement therapy

Value Proposition· Identifies targets for modulation of retinal Muller glia-derived neurogenesis.· Demonstrates efficacy of adeno-associated virus induced retinal Muller glia-derived neurogenesis.· Combines viral constructs and small molecules to generate specific subtypes of retinal Muller glia-derived neurons.· Applicable...

Published: 5/10/2024 | Inventor(s): Seth Blackshaw, Thanh Hoang

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Cell Therapies

A method to enhance delivery and editing efficiencies of CRISPR-Cas9

Value Proposition· Mechanical tuning of stiffness and viscoelasticity results in higher editing efficiency and requires less transfection reagents compared to traditional plasmid-based CRISPR-Cas9 methods. · Enhanced cell-substrate interactions between the cells and gels leads to greater uptake of nanoparticles, quicker onset of gene editing,...

Published: 5/10/2024 | Inventor(s): Luo Gu, Joon Eoh

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools

Compositions and Methods of Increasing RNA Translation

Value Proposition mRNA use for therapeutic purposes has proven useful in treating a wide array of diseases. Major challenges of mRNA therapies include immunogenicity, poor expression, and low stability. This therapy contains modifications improving mRNA stability, efficiency, and immunogenicity. This technology allows for the translation of almost...

Published: 5/10/2024 | Inventor(s): Jeffery Coller, Zachary Mandell

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Vaccines

Improving the sensitivity of CRISPR off-target detection through modulation of DNA repair

Value Proposition:· Utilizes components of existing workflow to better detect off-target gene editing· Capable for use in in vivo or in vitro settings· Maximizes impact of CRISPR-Cas9 in therapeutic developmentTechnology Description· Researchers at Johns Hopkins have developed a method to detect off-target editing with high...

Published: 5/10/2024 | Inventor(s): Roger Zou, Yang Liu, Taekjip Ha, Oscar Reyes Gaido

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Identification of DNA Polymerase Theta Inactivation Mechanism

Unmet NeedLoss of DNA repair is an early and frequent event in the growth of tumors, occurring in 40 to 50% of breast, lung and ovarian cancer patients. The inability to repair damaged DNA provides a selective growth advantage to tumor cells as this results in genetic instability and enhanced mutation rates, which can drive tumor growth. These DNA...

Published: 5/9/2024 | Inventor(s): Marc Greenberg, Daniel Laverty

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Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Cell Therapies

Bioreducible Poly(beta-amino ester)s for siRNA Delivery

C12218: Efficient Delivery Vehicle for Controlled Gene Knockdown Novelty: This technology comprises the use of bioreducible polymer based nanoparticle system that can release siRNA cargo to the cytoplasm of cells to knockdown target gene expression in tissues. Value Proposition: Gene therapy is a developing medical field and there is a need for...

Published: 5/9/2024 | Inventor(s): Kristen Kozielski, Stephany Tzeng, Jordan Green

Keywords(s): Biologics, Brain Cancer, Cancers, Cell Therapy, Disease Indication, Drug Delivery Vehicle, Glioma, Nucleic Acid, Polymers, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma

Novel stem-cell based therapeutic for retinal and macular repair

Unmet Need / Invention Novelty: Currently, there are limited options for patients diagnosed with degenerative macular diseases, with available options reducing the rate of degeneration rather than repairing the diseased retinal tissue. There is an unmet need to develop a novel therapeutic for macular degenerations that repairs diseased tissue. Technical...

Published: 5/10/2024 | Inventor(s): Mandeep Singh, Robert Johnston, Kiara Eldred, Katarzyna Hussey, Sarah Hadyniak, Christina McNerney

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

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