Search Results - seth+blackshaw

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Controlling homeostatic regulatory circuitry in hypothalamus

Value Proposition· Identifies targets for modulation of tanycyte-derived neurogenesis.· Demonstrates efficacy of small molecule induction of tanycyte-derived neurogenesis.· Combines viral constructs and small molecules to generate specific subtypes of tanycyte-derived neurons.· Applicable to a broad range of hypothalamic...

Published: 5/10/2024 | Inventor(s): Seth Blackshaw, Sooyeon Yoo, Leighton Duncan

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Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Stem Cells

Conversion of retinal glia into neurons for cell replacement therapy

Value Proposition· Identifies targets for modulation of retinal Muller glia-derived neurogenesis.· Demonstrates efficacy of adeno-associated virus induced retinal Muller glia-derived neurogenesis.· Combines viral constructs and small molecules to generate specific subtypes of retinal Muller glia-derived neurons.· Applicable...

Published: 5/10/2024 | Inventor(s): Seth Blackshaw, Thanh Hoang

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Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Cell Therapies

Method for using alternative splicing to control specificity of gene therapy

Unmet NeedViral-based gene therapy holds tremendous promise for the treatment of human diseases. Using genetically engineered carriers called vectors to deliver genes into cells, gene therapy can help replace a mutated gene with a healthy copy or even introduce a new gene into the body to fight a disease. However, an important concern when designing...

Published: 5/9/2024 | Inventor(s): Jonathan Ling, Seth Blackshaw

Keywords(s): Drug Delivery Mechanism, Gene Therapy, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Vectors & Plasmids

Novel universal stem cell-based therapy for the treatment of retinal diseases

Unmet Need / Invention Novelty: Gene augmentation therapy, the current technology for treatment of inherited retinal diseases, is limited by its 1) small cargo capacity which challenges the delivery of larger genes 2) ability to target only a single genetic mutation, and thus disease subtype, at a time, and 3) applicability only to recessive diseases...

Published: 5/10/2024 | Inventor(s): Mandeep Singh, Seth Blackshaw, Robert Johnston, Jiang Qian, Ying Liu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

Efficient generation of retinal photoreceptors from stem/progenitor cells.

Unmet NeedApproximately 253 million people worldwide live with vision impairment. Of those with vision impairment, approximately 15% are blind. Most human blindness is caused by the dysfunction or death of retinal photoreceptors. For many eye disorders, there is no way to reverse photoreceptor loss, and efforts to treat vision loss are aimed at slowing...

Published: 5/9/2024 | Inventor(s): Seth Blackshaw, Brian Clark, Richard Gronostajski

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Ophthalmology > Retinopathy, Technology Classifications > Therapeutic Modalities > Biologics