Search Results - mouse+cell+lines

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Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 6/13/2024 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Pkd1 mouse models

We have introduced lox P sites into introns 2 and 4 of the mouse Pkdl gene which allows its regulated inactivation. Mutations in human PKD1 account for at-85% of all cases of human autosomal dominant polycystic kidney disease. We have shown that we can recapitulate a human-like disease presentation using inducible Cre-recombinases. This model is a powerful...

Published: 6/13/2024 | Inventor(s): Gregory Germino, Heiner Westphal, Klaus Piontek

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Hypoxia-inducible factor reporter cell lines

Unmet NeedLow oxygen levels are a characteristic of many types of solid tumors. High levels of HIF1α, the transcription factor responsible for energy utilization under hypoxic conditions, has been implicated in tumor growth and resistance, angiogenesis, and poor patient prognosis. For these reasons, HIF1α remains an attractive target for novel cancer...

Published: 6/13/2024 | Inventor(s): Peter Espenshade, Wei Shao

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Cell Lines

Efficient generation of retinal photoreceptors from stem/progenitor cells.

Unmet NeedApproximately 253 million people worldwide live with vision impairment. Of those with vision impairment, approximately 15% are blind. Most human blindness is caused by the dysfunction or death of retinal photoreceptors. For many eye disorders, there is no way to reverse photoreceptor loss, and efforts to treat vision loss are aimed at slowing...

Published: 6/13/2024 | Inventor(s): Seth Blackshaw, Brian Clark, Richard Gronostajski

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Ophthalmology > Retinopathy, Technology Classifications > Therapeutic Modalities > Biologics

TC-1 (Po)

C03436: TC-1 (Po) Technical Details:This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential tumor markers in cancer vaccine experiments. Primary lung epithelial cells from C57BL/6 mice were immortalized with HPV-16 E6 and E7 and then transformed with the activated ras oncogene. This transformation...

Published: 6/13/2024 | Inventor(s): T.c. Wu

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines, Other Virus, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses

GDF11 Flox Mouse Line

Brief OverviewJHU researchers generated the GDF11 flox mouse line by inserting a loxP site upstream of exon 2 and a floxed neo cassette downstream of exon 3. Cre mediated recombination was then used to remove the neo cassette leaving exons 2 and 3 floxed (Molecular Image Detail). Detailed Technology OverviewMyostatin (Mstn) and growth/differentiation...

Published: 6/13/2024 | Inventor(s): Se-Jin Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

miR-143/145 conditional knockout mice

Unmet NeedThe miR-143/145 microRNA cluster has been implicated in colon cancer and other epithelial tumors, but investigation of its role in pathogenesis requires a research tool in which miR-143/145 expression can be modulated in specific cell types. Technology OverviewJohns Hopkins researchers generated a conditional knockout allele for the miR-143/145...

Published: 6/13/2024 | Inventor(s): Joshua Mendell, Raghu Chivukula, Guanglu Shi

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models

Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 6/13/2024 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

HPV-16 H-2 Db Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell Line

UNMET NEEDHuman papillomaviruses, particularly HPV-16, are associated with most cervical cancers and their precursors. E7 is an oncogenic HPV protein that is expressed in most HPV-positive cervical carcinomas and plays an important role in the initiation and maintenance of cellular transformation. Accordingly, vaccines targeting the E7 protein appear...

Published: 6/13/2024 | Inventor(s): T.c. Wu

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Research Tool, Infectious Diseases, Mouse Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Generation of stable mouse neuroblastoma N2a cells that express either wild-type human APP695 N2a APP695wt or human APP695swe N2a APP695swe

INVENTION NOVELTY: Researchers have generated transgenic mouse N2a neuroblastoma cells that stably express wild-type or mutated APP, respectively. C-terminally myc-tagged wild-type APP, or APP carrying the Swedish familial Alzheimer's disease (FAD)-specific amino acid substitution were cloned in plasmid pCB6 under control of CMV promoter. Next,...

Published: 6/13/2024 | Inventor(s): Sangram Sisodia

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

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