Search Results - viral+infections

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Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 5/9/2024 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 5/9/2024 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

B7-DC Variants in the Stimulation of Immune Responses

Unmet NeedUnfortunately, many human tumor cells have evolved ways of deactivating the body’s immune system by expressing inhibitory signals (e.g., PD-L1, CTLA-4) on tumor cell surfaces. As a consequence, there is a pressing need for novel immunotherapies that would allow immune cells to bypass specific inhibitory signals on tumor cells and carry out...

Published: 5/9/2024 | Inventor(s): Lieping Chen

Keywords(s): Bacterial Infections, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Hepatitis C virus E1E2 genes stimulating development of broadly neutralizing antibodies

Unmet Need185 million people worldwide are infected with Hepatitis C (HCV). It is a major cause of liver failure and hepatocellular carcinoma. Recent development of potent, oral, interferon-free therapies have improved treatment of HCV significantly, but treatment alone is unlikely to eradicate the disease. There remain the issues of therapy being costly,...

Published: 5/9/2024 | Inventor(s): Justin Bailey, James Crowe, Andrew Flyak, George Shaw, Stuart Ray

Keywords(s): Biologics, Disease Indication, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Ozonides forms of artemisinins inhibit cytomegalovirus (CMV) replication in vitro and in vivo

INVENTION NOVELTY: This technology involves the use of a derivative of artemisinin as a new therapy for Cytomegalovirus (CMV) infection.VALUE PROPOSITION: CMV infection is recognized as a cause of morbidity and mortality, especially in immunocompromised individuals. CMV is also the most common viral infection in solid organ transplant recipients. Several...

Published: 5/9/2024 | Inventor(s): Ravit Boger, Jonathan Vennerstrom

Keywords(s): Antagonists/Inhibitors, Cytomegalovirus, Disease Indication, Dosed Therapeutic, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

HPV-16 H-2 Db Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell Line

UNMET NEEDHuman papillomaviruses, particularly HPV-16, are associated with most cervical cancers and their precursors. E7 is an oncogenic HPV protein that is expressed in most HPV-positive cervical carcinomas and plays an important role in the initiation and maintenance of cellular transformation. Accordingly, vaccines targeting the E7 protein appear...

Published: 5/9/2024 | Inventor(s): T.c. Wu

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Research Tool, Infectious Diseases, Mouse Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Generation of HPV-16 H-2 Kb-restricted E6 Peptide (aa 48-57)-specific CD8+ T Cell Line

ABSTRACT The HPV-16 E6-specific CD8+ T cell line is generated by vaccinating six to eight week old female C57BL/6 (H2-Kb) mice with 2ug of pcDNA3-CRT/E6 using a helium-driven gene gun. Mice received two boosts with the same regimen 1 and 2 weeks later. The resulted splenocytes were harvested, stimulated with irradiated TC-1 tumor cells in the presence...

Published: 5/9/2024 | Inventor(s): T.c. Wu

PrEP Application for Persons at Risk of HIV

Unmet NeedThere remains a need for new and improved initiatives to identify and successfully engage and retain those people who may be at high risk of HIV infection or are infected with HIV.Technical DetailsJHU researchers have designed a patient facing linkage, adherence and retention based application to support HIV prevention. The application serves...

Published: 5/9/2024 | Inventor(s): Jason Farley, Kelly Lowensen

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Physics, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

Mobile Health Support Intervention for Hepatitis C Linkage to Care and Hepatitis C Treatment Adherence Support

We have designed an e-health application that documents and supports community based hepatitis C linkage to care and treatment for patients diagnosed with hepatitis C (HCV). There are an estimated 3.2 million Americans in the United States infected with HCV. Only about 6% of individuals have been cured of their hepatitis C infections. The major prognosticator...

Published: 5/9/2024 | Inventor(s): Oluwaseun Falade-Nwulia, David Thomas, Mark Sulkowski, Robert Bollinger, Alex Niculescu, Kathleen Page, Larry Chang, Jane Mckenzie-White, Maunank Shah

Keywords(s): Disease Indication, Disease Management System, Healthcare Management, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Operations Management, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

Chromobacterium Csp_P as a versatile anti-malaria and anti-dengue mosquito-based transmission blocking agent

Unmet Need: Treatment and preventative measures against vector-borne diseases remain underdeveloped. With increasing resistance against drugs and insecticides, and a general lack of vaccines, there is an urgent need for disease transmission blocking strategies. Technical Details: Johns Hopkins researchers have developed a strategy using Chromobacterium...

Published: 5/9/2024 | Inventor(s): George Dimopoulos, Sarah Short, Jose Ramirez

Keywords(s): Biologics, Dengue Fever, Disease Indication, Infectious Diseases, Malaria, Parasitic Infections, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Dengue Fever, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

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