Search Results - epigenetic

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DNA methylation markers for metastatic prostate cancer

Value Proposition:· Detection of methylation patterns that are linked to prostate cancer development in an individual.· Enable development of a personalized treatment plan for individuals with aggressive prostate cancer.· Simultaneous determination of gene methylation and copy number. Technology DescriptionResearchers at Johns Hopkins...

Published: 5/9/2024 | Inventor(s): George Bova, William Nelson, Martin Aryee, William Isaacs, Srinivasan Yegnasubramanian

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Mechanism-of-action Biomarker, Methylation, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 5/9/2024 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Greater Promoter Methylation and Somatic Mutation Analyses Reveal Alterations in PAX, NOTCH, and TP53 Pathways Associated with Poor Survival in Head and Neck Cancer

Novel Biomarkers for Predicting Head & Neck Cancer RiskC12502Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting Head & Neck Cancer risk. Value Proposition: Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide with more than 500,000 new cases and 300, 000 deaths each...

Published: 5/9/2024 | Inventor(s): Christina Michailidi, David Sidransky, Rafael Guerrero-Preston

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, Head & Neck Cancer, Head and Neck Cancer, In Vitro Diagnostics, Methylation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Head & Neck Cancer

A Selective Inhibitor of Histone Demethylase LSD1

Unmet Need: Epigenetic regulation of gene expression is one mechanism that can be dysregulated in the development of diseases such as cancer and has specifically been implicated in the the development of therapeutic resistance mechanisms in cancer and tumor metastasis. There remains a significant need for the development of novel epigenetic therapeutic...

Published: 5/9/2024 | Inventor(s): Philip Cole, Shonoi Ming, Jay Kalin, Polina Prusevich

Keywords(s): Antagonists/Inhibitors, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics (Old), Methylation, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

C13826: Quantitative Determination of Nucleoside Analogue Drugs in Genomic DNA or RNA

Unmet Need:Hematologic and epithelial malignancies have been shown to progress by epigenetically silencing genes that code for tumor suppressors, cell cycle regulators or proteins involved in cell-cell interaction. Gene suppression occurs through promoter methylation and modification of histones. Drugs which are able to manipulate promoter methylation...

Published: 5/9/2024 | Inventor(s): Michelle Rudek-Renaut, Srinivasan Yegnasubramanian, Nicole Anders

Keywords(s): Analytical Method, Assay, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Research Tool, Methylation

Category(s): Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays

Paternal Sperm DNA Methylation as a Predictive Marker of Autism Risk

Unmet Need:Autism spectrum disorder (ASD), is a complex neurodevelopmental disorder that refers to a range of conditions characterized by challenges with behavior including social skills, communication, and repetitive behaviors, all of which have ranges and severities that are patient specific. Currently, there are no medical tests such as a scan or...

Published: 5/9/2024 | Inventor(s): Andrew Feinberg, Margaret Fallin

Keywords(s): Autism, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Autism, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

Engulfment Gene GULP1 as a Functional Tumor Suppressor in Urothelial Carcinoma

Invention Novelty:The technology identifies a novel biomarker to detect the presence of bladder cancer via a urine test. The technology could be coupled with existing urine-based cancer tests to improve sensitivity as a diagnostic or to test drug efficacy. Value Proposition:Bladder cancer (BC) is the 6th most common cancer in the US, with approximately...

Published: 5/9/2024 | Inventor(s): Mohammad Hoque, Masamichi Hayashi, Elisa Guida

Keywords(s): Biomarker, Bladder Cancer, Cancers, Disease Indication, Epigenetic, Methylation, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics, Urothelial Carcinoma

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Bladder Cancer, Clinical and Disease Specializations > Oncology > Urothelial Carcinoma, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Urology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Using DNA Methylation Markers To Create a Molecular Staging Paradigm for Solid Malignancies and To Predict Cancer Recurrence and Patient Survival

Technology: Currently, cancer recurrence in solid malignancies occurs in many patients after complete curative surgery despite no additional histological evidence of remaining cancer outside the area of resection, especially in the surrounding lymph nodes. It is believed that in patients with recurrent disease, micrometastases reside that are undetectable...

Published: 5/9/2024 | Inventor(s): James Herman, Stephen Baylin, Malcolm Brock

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics

Histone Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method

METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETICMACHINERYJHU REF: C13083Invention novelty: A genetically encoded histone reporter allele system which can be utilized for high throughput screening in in vitro cellular systems.Value Proposition: Epigenetic modifications are thought to be one of the critical mechanisms that mediate gene-environment...

Published: 5/9/2024 | Inventor(s): Harry Dietz, Hans Bjornsson

Keywords(s): Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, Genetic Disorders, In Vitro Diagnostics (Old), In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Diagnostics > Biomarkers

A DNA methylation and genotype specific biomarker of suicide attempt

Novel Biomarkers for Predicting Suicide RiskJHU REF: [C12394]Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting suicide risk. Value Proposition: Almost 30,000 people die of suicide each year in the United States, and 1 million people die worldwide. In the teenage population, it is the second leading cause of...

Published: 5/9/2024 | Inventor(s): Holly Wilcox, Zachary Kaminsky

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Diagnostics (Old), Methylation, Prognostic Biomarker, Psychiatric Diseases, Suicidal Impulses, Suicide/Suicidal Impulses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

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