Search Results - william+nelson

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DNA methylation markers for metastatic prostate cancer

Value Proposition:· Detection of methylation patterns that are linked to prostate cancer development in an individual.· Enable development of a personalized treatment plan for individuals with aggressive prostate cancer.· Simultaneous determination of gene methylation and copy number. Technology DescriptionResearchers at Johns Hopkins...

Published: 5/9/2024 | Inventor(s): George Bova, William Nelson, Martin Aryee, William Isaacs, Srinivasan Yegnasubramanian

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Mechanism-of-action Biomarker, Methylation, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

RepairSwitch Assay for Functional DNA Repair Assessment

Unmet NeedDNA Double-strand breaks (DSB) occur when it is exposed to ionizing radiation and can result in cancerous mutations when repaired via homologous recombination (HR) or non-homologous end-joining (NHEJ) [1]. Cancer cells rely on these mutagenic repair mechanisms for survival [2]. But, the dynamics between the two repair pathways is unclear....

Published: 5/10/2024 | Inventor(s): Srinivasan Yegnasubramanian, Chaya Steinberg, William Nelson

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays

Induction of Synthetic Lethality with Epigenetic Therapy (ISLET) by Combined DNA Methyltransferase and Aurora Kinase Inhibition

Invention NoveltyThis invention is a novel paradigm for the induction of synthetic lethality through epigenetic modulations. This can induce functionality and efficacy of therapeutics against cancer cells that may have resistance to each therapeutic alone. Value PropositionThe complex and adaptive nature of the host of diseases termed cancer poses significant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, William Nelson, Ajay Vaghasia, Philipp Nuhn

Keywords(s): Cancers, Chemotherapy/Targeted Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

C12052 - LAPC4-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New LAPC4-CR cell line which shows properties of castration resistant tumors, both in vitro and in vivo.Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

C12051 - VCaP-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New VCaP-CR cell line that shows properties of castration resistant tumors, both in vitro and in vivo. Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

5-hydroxymethylcytosine in Human Cancers

C11663: 5hmC: A Novel Marker for Cancer DetectionNovelty: The invention is a novel marker that can be detected in cancers using immunohistochemical (IHC) staining methods.Value Proposition: Cancers are often diagnosed in advanced stages, jeopardizing cancer patients’ chance to survive. This technique can detect different types of solid cancers...

Published: 5/9/2024 | Inventor(s): William Nelson, Angelo Demarzo, Alcides Chaux, Srinivasan Yegnasubramanian, Michael Haffner

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

C05053: Small Molecules Epigenetic Inhibitors for Cancer Prevention and Treatment.

C05053: Small Molecules Epigenetic Inhibitors for Cancer Prevention and Treatment.Value Proposition: • Compounds represent first in class small molecule agents for inhibition of MBD2 activity. • Reversible inhibition. • Truly epigenetic agents, unlike other epigenetic drugs which appear to have cytotoxic effects independent of epigenetic...

Published: 5/9/2024 | Inventor(s): Xiaohui Lin, Zachery Reichert, Traci Speed, Srinivasan Yegnasubramanian, William Nelson

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Genetic Disorders, Non-novel, Off-the-shelf, Predicted Novelty, Sickle Cell Anemia, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

COMPARE-MS: A Novel Technique for Rapid, Sensitive, And Accurate Detection of DNA Methylation

C04871: COMPARE-MS: A Novel Technique for Rapid, Sensitive, And Accurate Detection of DNA MethylationTechnical Details: Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. The rapid and sensitive detection of DNA hypermethylation can aid in cancer diagnosis and risk stratification but its detection...

Published: 5/9/2024 | Inventor(s): Xiaohui Lin, Srinivasan Yegnasubramanian, Angelo Demarzo, William Nelson

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Antibody to Human DNA Methyltransferase 1

C04328: Antibody to Human DNA Methyltransferase 1 Technical Details: We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human DNMT1 (the sub-contractor was provided with the peptide sequence, synthesized the peptide, injected rabbits, and collected the immune sera; we characterized the antibodies and...

Published: 5/9/2024 | Inventor(s): Angelo Demarzo, William Nelson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Peptides, Polyclonal Antibodies, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors