Search Results - srinivasan+yegnasubramanian

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Prodrug for Immunological and Oncological Therapy

Unmet NeedApproximately 1.24 million hematological cancer cases occur each year, accounting for approximately 6% of all cancer cases (Bristol Myers Squibb). Currently, standard treatment strategies include chemotherapy, radiation therapy, and stem cell transplants. However, there exist several major drawbacks for each method. Stem cell transplants can...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, Franco D'alessio, Pavel Majer, Marcela Krecmerova, Srinivasan Yegnasubramanian

Keywords(s): Blood Cancer, Cancers, Disease Indication, Inflammatory Disorders, Respiratory Infections, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Small Molecules

DNA methylation markers for metastatic prostate cancer

Value Proposition:· Detection of methylation patterns that are linked to prostate cancer development in an individual.· Enable development of a personalized treatment plan for individuals with aggressive prostate cancer.· Simultaneous determination of gene methylation and copy number. Technology DescriptionResearchers at Johns Hopkins...

Published: 5/9/2024 | Inventor(s): George Bova, William Nelson, Martin Aryee, William Isaacs, Srinivasan Yegnasubramanian

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Mechanism-of-action Biomarker, Methylation, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

RepairSwitch Assay for Functional DNA Repair Assessment

Unmet NeedDNA Double-strand breaks (DSB) occur when it is exposed to ionizing radiation and can result in cancerous mutations when repaired via homologous recombination (HR) or non-homologous end-joining (NHEJ) [1]. Cancer cells rely on these mutagenic repair mechanisms for survival [2]. But, the dynamics between the two repair pathways is unclear....

Published: 5/10/2024 | Inventor(s): Srinivasan Yegnasubramanian, Chaya Steinberg, William Nelson

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays

Induction of Synthetic Lethality with Epigenetic Therapy (ISLET) by Combined DNA Methyltransferase and Aurora Kinase Inhibition

Invention NoveltyThis invention is a novel paradigm for the induction of synthetic lethality through epigenetic modulations. This can induce functionality and efficacy of therapeutics against cancer cells that may have resistance to each therapeutic alone. Value PropositionThe complex and adaptive nature of the host of diseases termed cancer poses significant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, William Nelson, Ajay Vaghasia, Philipp Nuhn

Keywords(s): Cancers, Chemotherapy/Targeted Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

A New Method to Suppress Background Noise in Stimulated Emission Depletion (STED) Nanoscopy

Unmet NeedDifferentiating small features, such a membrane fibrils in a cell, or small entities, such as viruses, is made possible by high resolution fluorescence imaging. Stimulated Emission Depletion (STED) Nanoscopy has proven to produce images that can overcome the diffraction limit and provide nanometer resolution of fluorescently labeled samples....

Published: 5/9/2024 | Inventor(s): Taekjip Ha, Jong-Chan Lee, Ye Ma

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging

C13826: Quantitative Determination of Nucleoside Analogue Drugs in Genomic DNA or RNA

Unmet Need:Hematologic and epithelial malignancies have been shown to progress by epigenetically silencing genes that code for tumor suppressors, cell cycle regulators or proteins involved in cell-cell interaction. Gene suppression occurs through promoter methylation and modification of histones. Drugs which are able to manipulate promoter methylation...

Published: 5/9/2024 | Inventor(s): Michelle Rudek-Renaut, Srinivasan Yegnasubramanian, Nicole Anders

Keywords(s): Analytical Method, Assay, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Research Tool, Methylation

Category(s): Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays

Cell Line Microarray of Seven NCI60 Cell Lines

TITLE: Cell Line Microarray of Commonly used Cancer Cell Lines CASE NUMBER: C14193 UNMET NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations...

Published: 5/9/2024 | Inventor(s): Angelo Demarzo, David Esopi, Bonnie Gambichler, Srinivasan Yegnasubramanian

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines

C12052 - LAPC4-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New LAPC4-CR cell line which shows properties of castration resistant tumors, both in vitro and in vivo.Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

C12051 - VCaP-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New VCaP-CR cell line that shows properties of castration resistant tumors, both in vitro and in vivo. Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 5/9/2024 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

5-hydroxymethylcytosine in Human Cancers

C11663: 5hmC: A Novel Marker for Cancer DetectionNovelty: The invention is a novel marker that can be detected in cancers using immunohistochemical (IHC) staining methods.Value Proposition: Cancers are often diagnosed in advanced stages, jeopardizing cancer patients’ chance to survive. This technique can detect different types of solid cancers...

Published: 5/9/2024 | Inventor(s): William Nelson, Angelo Demarzo, Alcides Chaux, Srinivasan Yegnasubramanian, Michael Haffner

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

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