Search Results - william+isaacs

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DNA methylation markers for metastatic prostate cancer

Value Proposition:· Detection of methylation patterns that are linked to prostate cancer development in an individual.· Enable development of a personalized treatment plan for individuals with aggressive prostate cancer.· Simultaneous determination of gene methylation and copy number. Technology DescriptionResearchers at Johns Hopkins...

Published: 5/9/2024 | Inventor(s): George Bova, William Nelson, Martin Aryee, William Isaacs, Srinivasan Yegnasubramanian

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Mechanism-of-action Biomarker, Methylation, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

RNA In Situ Hybridization Assay (RISH) for the Detection of Prostate Cancer Cells in Urine

Unmet NeedProstate cancer is one of the most commonly diagnosed cancers in the male population; roughly one out of ten men will be diagnosed at some point in their lives. Efficient screening and accurate diagnosis is a public health imperative due to the large potential patient population. Prostate cancer is usually diagnosed following an abnormal physical...

Published: 5/9/2024 | Inventor(s): Jun Luo, Christian Pavlovich, William Isaacs, Jillian Eskra

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prostate Cancer, Risk Stratification

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Novel biomarkers for prostate cancer diagnosis

Novelty: Five HOXB13 markers (G84E, L144P, Y88D, G216C, R229G) for identifying men with high risk of developing early-onset and hereditary prostate cancer. Value Proposition: Currently, there are no reliable genetic markers to assess risk for prostate cancer and the PSA test is known to lead to over-diagnosis of men with prostate cancer. To address...

Published: 5/9/2024 | Inventor(s): Kathleen Cooney, William Isaacs

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Prognostic Biomarker, Prostate Cancer, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers