Search Results - blood+cancer

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Prodrug for Immunological and Oncological Therapy

Unmet NeedApproximately 1.24 million hematological cancer cases occur each year, accounting for approximately 6% of all cancer cases (Bristol Myers Squibb). Currently, standard treatment strategies include chemotherapy, radiation therapy, and stem cell transplants. However, there exist several major drawbacks for each method. Stem cell transplants can...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, Franco D'alessio, Pavel Majer, Marcela Krecmerova, Srinivasan Yegnasubramanian

Keywords(s): Blood Cancer, Cancers, Disease Indication, Inflammatory Disorders, Respiratory Infections, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Small Molecules

FLT3/ITD Mouse Model for Acute Myeloid Leukemia (AML)

Unmet Need: Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD...

Published: 5/9/2024 | Inventor(s): Donald Small

Keywords(s): Acute Myeloid Leukemia, Blood Cancer, Cancers, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

MMSET Knock Out and Knock Down Multiple Myeloma Cells

C10575: MMSET Knock Out and Knock Down Multiple Myeloma Cells Value Proposition: • Effective knockout/knockdown Multiple Myeloma cells line for the study of t(4;14)(p16;q32), worst prognostic subgroup in Multiple Myeloma Patients. Technical Details: Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal...

Published: 5/9/2024 | Inventor(s): Josh Lauring, Ben Ho Park

Keywords(s): Basic Research Biomarker, Blood Cancer, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vitro Research Tool, Multiple Myeloma

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

SOCS1 Promoter Methylation Identifies a Target for JAK/STAT Activation

C03870: Identification and treatment of cancers with epigenetic silencing of SOCS/CIS genes.Value Proposition: • Methods for early detection, progression, and recurrence of hematological malignancies • Predictive biomarker useful for determining sensitivity to JAK inhibitors • Methods to aid in risk assessment of primary and secondary...

Published: 5/9/2024 | Inventor(s): Curtis Harris, Hirohide Yoshikawa, James Herman

Keywords(s): Biologics, Biomarker, Blood Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gene Therapy, Hematologic Malignancies, In Vitro Diagnostics, In Vitro Research Tool, Multiple Myeloma, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics