Search Results - cell+lines

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Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 5/9/2024 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Isogenic SF3B1 cell lines for drug discovery

SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...

Published: 5/9/2024 | Inventor(s): Ben Ho Park, William Dalton

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines

Pkd1 mouse models

We have introduced lox P sites into introns 2 and 4 of the mouse Pkdl gene which allows its regulated inactivation. Mutations in human PKD1 account for at-85% of all cases of human autosomal dominant polycystic kidney disease. We have shown that we can recapitulate a human-like disease presentation using inducible Cre-recombinases. This model is a powerful...

Published: 5/9/2024 | Inventor(s): Gregory Germino, Heiner Westphal, Klaus Piontek

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

ENGINEERED CELLS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) OR A MODIFIED FORM THEREOF AND RELATED METHODS

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Various treatment strategies, including surgery, radiation and chemotherapy, exist for prostate cancer but their success depends on the stage of the cancer at diagnosis. Novel...

Published: 5/9/2024 | Inventor(s): Martin Pomper, David Huss, Hyam Levitsky, Il Minn

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Large Animal Cell Lines, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies

GATA3 wild type MCF-7 breast cancer cells GATA3 D336fs*17 mutant CAMA1 breast cancer cells

Unmet NeedMutations in the transcription factor-encoding gene GATA3 are highly prevalent in breast cancer but the functional role of mutant GATA3 in malignancy remains unclear due in part to the absence of appropriate research tools. Human breast cancer cell lines with mutant and wild-type GATA3, including MCF-7 and CAMA1, respectively, are commercially...

Published: 5/9/2024 | Inventor(s): Josh Lauring, John Gustin

Keywords(s): Basic Research Biomarker, Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Research Tools > Cell Lines

Hypoxia-inducible factor reporter cell lines

Unmet NeedLow oxygen levels are a characteristic of many types of solid tumors. High levels of HIF1α, the transcription factor responsible for energy utilization under hypoxic conditions, has been implicated in tumor growth and resistance, angiogenesis, and poor patient prognosis. For these reasons, HIF1α remains an attractive target for novel cancer...

Published: 5/9/2024 | Inventor(s): Peter Espenshade, Wei Shao

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Cell Lines

14-3-3 Mediates a p53-Induced G2 Arrest

C03338: 14-3-3 Mediates a p53-Induced G2 Arrest Technical Details: Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Through a quantitative...

Published: 5/9/2024 | Inventor(s): Heiko Hermeking, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Cell Lines, Cell Signaling, Discovery/Research Tools, Disease Indication, Gene Therapy, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Pharmakodynamic Biomarker, Research Reagent, Single, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Partitioning of Human Mesenchymal Stem Cells based on CD107a Expression

Unmet NeedAutologous (obtained from the same individual) stem cell therapies are a promising avenue for the treatment of tissue defects, especially defects of bone and soft tissues. The burden of treating and/or repairing tissue defects is substantial: 2.2 million surgeries are performed each year to address bone defects, costing an estimating $56 billion....

Published: 5/9/2024 | Inventor(s): Aaron James

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Scalable Method for Multiplexed Genome Editing

Unmet NeedTargeted genome editing has become a very important genetic tool with broad applications across various areas of science including but not limited to basic science, the pharmaceutical industry, and translational medicine. Presently, one of the most commonly used site-specific, genome editing systems is CRISPR/Cas9, as it enables insertion...

Published: 5/9/2024 | Inventor(s): Chulan Kwon, Renjun Zhu, Amir Saberi

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids

Efficient generation of retinal photoreceptors from stem/progenitor cells.

Unmet NeedApproximately 253 million people worldwide live with vision impairment. Of those with vision impairment, approximately 15% are blind. Most human blindness is caused by the dysfunction or death of retinal photoreceptors. For many eye disorders, there is no way to reverse photoreceptor loss, and efforts to treat vision loss are aimed at slowing...

Published: 5/9/2024 | Inventor(s): Seth Blackshaw, Brian Clark, Richard Gronostajski

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Ophthalmology > Retinopathy, Technology Classifications > Therapeutic Modalities > Biologics

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