Search Results - david+sidransky

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Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 5/9/2024 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Greater Promoter Methylation and Somatic Mutation Analyses Reveal Alterations in PAX, NOTCH, and TP53 Pathways Associated with Poor Survival in Head and Neck Cancer

Novel Biomarkers for Predicting Head & Neck Cancer RiskC12502Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting Head & Neck Cancer risk. Value Proposition: Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide with more than 500,000 new cases and 300, 000 deaths each...

Published: 5/9/2024 | Inventor(s): Christina Michailidi, David Sidransky, Rafael Guerrero-Preston

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, Head & Neck Cancer, Head and Neck Cancer, In Vitro Diagnostics, Methylation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Head & Neck Cancer

Global DNA Hypomethylation as Biomarker for Clinical Detection, Inflammation Severity, and Disease Progression in Gastric Cancer

C11444: Novel Biomarker for Diagnosis of Gastric CancerNovelty: The reported technology identifies a novel biomarker for clinical detection, inflammation severity, and disease progression in gastric cancer.Value Proposition: The technology outlined is a diagnostic technique to detect a biomarker known to play a major role in gastric carcinogenesis....

Published: 5/9/2024 | Inventor(s): David Sidransky, Rafael Guerrero-Preston

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Gastric Cancer, In Vitro Diagnostics, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Gastric Cancer

PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS

UNMET NEEDChronic environmental exposure induces cancer stem cells (CSCs) with SOX2 overexpression, one of the most important CSC factor for urothelial cancer (UC). COX2 and YAP1 coordinately regulate SOX2 expression, and mutually compensate for the reduction of expression of SOX2 to maintain CSCs. Thus targeting the COX2/YAP/SOX2 signaling axis eliminates...

Published: 5/9/2024 | Inventor(s): Mohammad Hoque, David Sidransky, Akira Oki

Keywords(s): Antagonists/Inhibitors, Bladder Cancer, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Small Molecules, Targeted Therapy/Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Urothelial Carcinoma

Category(s): Clinical and Disease Specializations > Oncology > Bladder Cancer, Clinical and Disease Specializations > Oncology > Urothelial Carcinoma, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets

Optimal Use of a Panel of Methylation Markers with GSTP1 Hypermethylation in the Diagnosis

C04609: Optimal Use of a Panel of Methylation Markers with GSTP1 Hypermethylation in the DiagnosisValue Proposition: • Detection and diagnosis of bladder, renal, and prostate cancers with increased improvement over histology alone • Method to detect the recurrence of cancer in a patient currently undergoing treatment or previously treated...

Published: 5/9/2024 | Inventor(s): David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

BRAF Mutation Occurs in a Majority of Papillary Thyroid Carcinoma

Unmet Need:Papillary thyroid cancer (PTC) is the most common thyroid cancer, accounting for about 80% of thyroid malignancies. Although PTC is usually indolent and curable with surgical thyroidectomy followed by radioiodine treatment, many patients do have recurrence and some become incurable and will die from the disease. Consequently, it is important...

Published: 5/9/2024 | Inventor(s): David Sidransky, Michael Xing, Yoram Cohen

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics, Thyroid Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Endocrinology, Clinical and Disease Specializations > Oncology > Thyroid Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Functional Identification of Methylated Cancer Genes

C04028: Functional Identification of Methylated Cancer GenesValue Proposition: • Molecular biomarkers frequently inactivated in primary tumors which displayed clear tumor suppressive activity • Rapid and robust method Technical Details: BACKGROUND Cancer of the esophagus is the eighth most common malignancy and ranks as the sixth most frequent...

Published: 5/9/2024 | Inventor(s): Hiromu Suzuki, Stephen Baylin, James Herman, David Sidransky

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

A Genomic Screen for Genes Upregulated By Demethylation and HDAC Inhibition in Human Colorectal Cancer

C03982: Genomic Screen for Epigenetically Silenced Genes Associated with Colorectal Cancer & Novel Biomarkers for the Detection & Diagnosis of Human Colorectal CancerValue Proposition: Comprehensive biomarker panel for sensitive detection and diagnosis of colon and gastric cancersTechnical Details: BACKGROUND Although cancers generally are considered...

Published: 5/9/2024 | Inventor(s): Hiromu Suzuki, David Sidransky, James Herman, Stephen Baylin

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Molecular Characteristics of Non-small Cell Lung Cancer

C03957: Molecular Characteristics of Non-small Cell Lung Cancer Technical Details: We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as...

Published: 5/9/2024 | Inventor(s): David Sidransky, Mariana Nacht, Stephen Madden, Tatiana Dracheva, Jen Jin

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Lung Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology