Search Results - clinical+and+disease+specializations+%3e+infectious+diseases+%3e+human+papillomavirus

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Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 5/9/2024 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

HPV-16 H-2 Db Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell Line

UNMET NEEDHuman papillomaviruses, particularly HPV-16, are associated with most cervical cancers and their precursors. E7 is an oncogenic HPV protein that is expressed in most HPV-positive cervical carcinomas and plays an important role in the initiation and maintenance of cellular transformation. Accordingly, vaccines targeting the E7 protein appear...

Published: 5/9/2024 | Inventor(s): T.c. Wu

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Research Tool, Infectious Diseases, Mouse Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Generation of HPV-16 H-2 Kb-restricted E6 Peptide (aa 48-57)-specific CD8+ T Cell Line

ABSTRACT The HPV-16 E6-specific CD8+ T cell line is generated by vaccinating six to eight week old female C57BL/6 (H2-Kb) mice with 2ug of pcDNA3-CRT/E6 using a helium-driven gene gun. Mice received two boosts with the same regimen 1 and 2 weeks later. The resulted splenocytes were harvested, stimulated with irradiated TC-1 tumor cells in the presence...

Published: 5/9/2024 | Inventor(s): T.c. Wu

DNA Constructs to Make Papillomavirus Pseudovirions for HPV Types

These are codon-optimized DNA constructs for the expression of different HPV types major capsid protein, L1 and minor capsid protein, L2, in the vector pVITRO.This Material is also available at Addgene: https://www.addgene.org/Richard_Roden/Related Publication:■ Vaccine. 2010 Jun 17; 28(28): 4478–4486. ■

Published: 5/9/2024 | Inventor(s): Richard Roden

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), Infectious Diseases, Plasmid, Research Reagent, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Vectors & Plasmids, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Human Papillomavirus Virus-like-participle Protein

TITLEHuman Papillomavirus Virus-like-participle ProteinCASE NUMBERC04137ABSTRACTVirus-like particles (VLPs) are extraordinary molecules that resemble and mimic the structure of authentic viruses without being infectious. Since they do not contain any viral genetic material, they are able to elicit a strong immune response, without doing any actual...

Published: 5/9/2024 | Inventor(s): Raphael Viscidi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), Infectious Diseases, Other Virus, Research Reagent, Viral Infections, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools