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In vivo and in vitro Role of Lactosylceramide Synthase (LCS) in Angiogenesis and LCS (B1, 4GalT-V) as a Bio-marker for Human Colon Cancer

Description: C10539: Use of Biomarker for Colon Cancer Diagnosis Value Proposition: ADVANTAGES • Colon cancer biomarker is directly included in panels of biomarkers for use in needle biopsies of colon tissue for early detection and diagnosis. • Colon cancer is the second largest mortality after cardiovascular disease. 90% of colorectal cancers...

Published: 5/9/2024 | Inventor(s): Subroto Chatterjee

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Camera-based Hemoglobin Detection

Unmet NeedIn the United States, colorectal cancer is the third most deadliest cancer with approximately 150,000 new cases projected for 2021 (see ACS). Efforts for early detection and diagnosis of colorectal cancer involve colonoscopies as well as fecal immunohistochemical tests that examine stool for the presence of hemoglobin. Despite these measures...

Published: 5/10/2024 | Inventor(s): Simon Mathews, Amit Banerjee, Pankaj Pasricha

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Engineered Fibroblasts as Cell Therapy to Treat Cancer via Tumor Stroma Stabilization

Unmet Need / Invention Novelty: Carcinoma associated fibroblasts (CAFs) are associated with the development of high-grade malignancies of poor prognoses, as they facilitate cancer invasion and hinder anti-cancer drug delivery. In order to improve the long-term survival rate of pre-metastatic cancer patients, we report genetically engineered fibroblasts...

Published: 5/10/2024 | Inventor(s): Yun Chen, Wei-Hung Jung, Michael Betenbaugh, Franck Housseau

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Endoscope Localization Using Transmission Ultrasonography

Unmet NeedColonoscopies are one of the most frequently performed procedures in the United States, with over 14 million colonoscopies performed in the US each year. Colonoscopies can screen for colon cancer by identifying polyps, strictures, diverticulae, and other abnormalities. Accurate localization of the colonoscope tip is essential to pinpointing...

Published: 5/9/2024 | Inventor(s): James Taylor, Seth Goldstein

Keywords(s): Cancers, Colorectal Cancer, Disease Indication, Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Detection and Elimination of Colonic Co-colonization with Enterotoxigenic Bacteroides Fragilis and pks+ Escherichia Coli in the Prevention of Colon Cancer

Unmet NeedFamilial adenomatous polyposis (FAP) is a hereditary condition caused by a mutation in the APC tumor suppressor gene, with a reported incidence of 1 in 7,000 to 1 in 22,000 individuals. Patients with FAP develop thousands of colorectal polyps that will eventually become malignant, resulting in colorectal cancer later in life. The onset and...

Published: 5/9/2024 | Inventor(s): Cynthia Sears, Christine Craig, Drew Pardoll

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Instrument

Category(s): Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays

Genetic Alterations Related to Anti-EGFR Therapeutic Response

Unmet Need:Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are monoclonal antibodies, which prevent epidermal growth factor receptor (EGFR) activation. Several studies have identified alterations in KRAS and other genes...

Published: 5/9/2024 | Inventor(s): Livio Trusolino, Andrea Bertotti, Victor Velculescu, Vilmos Adleff, Eniko Papp

Keywords(s): Biomarker, Cancers, Colorectal Cancer, Disease Indication, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

MicroRNA Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation

TITLE: Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER: C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with...

Published: 5/9/2024 | Inventor(s): Stephen Meltzer, Alexandru Olaru

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Chronic Inflammatory Diseases, Cloning Reagents, Colorectal Cancer, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD), Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Therapeutic Matter, Therapeutics

Biofilm Formation to Define Risk for Colon Cancer

Biofilm Detection to Define Risk for Colon CancerJHU REF: C12695Invention novelty: This technology is a diagnostic method for identifying people at risk for colon cancer employing analysis of biopsy specimens for biofilm formation. Value Proposition:Colorectal cancer is the third most commonly diagnosed cancer in the world. According to the American...

Published: 5/9/2024 | Inventor(s): Drew Pardoll, Elizabeth Wick, Christine Craig, Cynthia Sears

Keywords(s): Assay, Cancers, Clinical Diagnostics, Colorectal Cancer, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

USP9x-deficient HCT116 and DLD-1 Cells

USP9X-deficient cancer cell linesJHU REF: [C11655]Invention novelty: The technology consists of colorectal cancer cell lines possessing a knockout mutation in the USP9X gene with/without an additional deletion of p53.Value PropositionThe cell lines present an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study...

Published: 5/9/2024 | Inventor(s): Dennis Harris, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

An Endoscopic Device and Method to Retrieve Tetherless Microtools

C11519: Improved Colon Biopsy Devices: Tetherless Microtools and Magnetic Deployment/ Retrieval EndoscopeNovelty: The device and method is used to retrieve tissue with minimally invasive and collects large numbers of samples.Value Proposition: Current colon biopsy methods include collection of many, relatively large samples from multiple areas in the...

Published: 5/9/2024 | Inventor(s): David Gracias, Anthony Kalloo, Mouen Khashab, Florin Selaru

Keywords(s): Cancers, Clinical Diagnostics, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics, In Vitro Research Tool, Interventional and Surgical Systems, Pathology Tools, Sample Collection Method, Surgical Instruments

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Colorectal Cancer

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