Search Results - gastrointestinal+disorders

17 Results

Sort By:

Treatment of Irritable Bowel Syndrome with Molybdenum

Unmet NeedIrritable Bowel Syndrome is a chronic and incurable gastrointestinal disorder that affects 3-20% of Americans depending on certain sociocultural and comorbid factors. A poorly understood condition, current treatments consist of antispasmodics, antidiarrheals, and dietary restrictions. Unable to alleviate all its symptoms, researchers are in...

Published: 5/9/2024 | Inventor(s): Pankaj Pasricha, Lian Sheng Liu, Qian Li, Alfred Spormann

Keywords(s): Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease (IBD), Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Gastroenterology > Irritable Bowel Disease

Gastric Sponge System and Use Thereof

Unmet NeedObesity affects approximately 30% of adults in the United States and continues to rise in prevalence. Surgical intervention is an effective obesity treatment that provides long lasting results. However, due to the high risk profile of surgical intervention, only patients diagnosed with class II obesity (BMI is between 35 and 40 with a significant...

Published: 5/9/2024 | Inventor(s): Anthony Kalloo, Mouen Khashab, Darrin Kent, Peter D'Aquanni, Brett Hampton

Keywords(s): Disease Indication, Drug Delivery Device, Gastrointestinal Disorders, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

Use of AHR Agonists to Prevent or Treat NEC in Premature Infants

UNMET NEED: Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants. The main risk factors for the development of NEC are prematurity, bacterial colonization and administration of formula feeds, which in the setting of an abnormal microbiome lead to enhanced signaling via toll like receptor 4...

Published: 5/9/2024 | Inventor(s): David Hackam, Chhinder Sodhi, Jun Liu, Peng Lu

Keywords(s): Agonists/Promoters, Disease Indication, Gastrointestinal Disorders, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Novel Hook and Catheter Designs for Gastrointestinal Perforation Closure

INVENTION NOVELTY This technology is a new device that allows for acquiring tissue and foreign bodies or closing openings in bodily tissue. VALUE PROPOSTITION Perforation is a potentially serious complication of diagnostic and therapeutic gastrointestinal endoscopy. Closure of any perforation endoscopically is preferable to avoid surgical intervention...

Published: 5/9/2024 | Inventor(s): Anthony Kalloo, Mouen Khashab, Robert Ragland, Darrin Kent, Eric Johnson

Keywords(s): Disease Indication, Gastrointestinal Disorders, Gastrointestinal Leaks & Perforations, Gastrointestinal Leaks and Perforations, Interventional and Surgical Systems

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology > Gastrointestinal Leaks & Perforations, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Gastroenterology

Smartphone Mobile Application for the Analysis of Infant Stool Color to Determine Gastrointestinal and Hepatobiliary Disease

Stool Color Card Smart Phone ApplicationJHU REF: [C12590] Invention novelty: Mobile device application (app) for analyzing stool color Value Proposition Abnormalities in stool color can provide important clues regarding diseases of the gastrointestinal tract and hepatobiliary system. Specifically, red or black stool can suggest gastrointestinal...

Published: 5/9/2024 | Inventor(s): Douglas Mogul

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Gastrointestinal Disorders, Measurement Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics

MicroRNA Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation

TITLE: Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER: C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with...

Published: 5/9/2024 | Inventor(s): Stephen Meltzer, Alexandru Olaru

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Chronic Inflammatory Diseases, Cloning Reagents, Colorectal Cancer, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD), Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Therapeutic Matter, Therapeutics

Human Enteroids

Invention Novelty: This invention establishes human enteroids as nontransformed cell culture models to understand human intestinal physiology and pathophysiology and the epithelial response, including host restriction, cell type restriction, and virus-induced fluid secretion. Value Proposition: Johns Hopkins researchers have developed novel,...

Published: 5/9/2024 | Inventor(s): Mark Donowitz, Olga Kovbasnjuk, Nicholas Zachos

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Treatment of Injury or Neurodegenerative Disorders of the Enteric Nervous System (ENS) that cause Gastrointestinal Dysfunctions for which There is No Effective Therapy

JHU Ref. C13755Title: Preconditioned BMSC Promote de novo Nerve Regeneration: Potential application in therapy of enteric nerve injury/disorders and vascularized composite allotransplantation (VCA) UNMET NEEDInjury or neurodegenerative disorders of the enteric nervous system (ENS) cause gastrointestinal dysfunctions for which there is no effective therapy,...

Published: 5/9/2024 | Inventor(s): Xuhang Li, Xiaohua Hou, Rong Lin

Keywords(s): Cell Therapy, Disease Indication, Gastrointestinal Disorders, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities

Three-dimensional Imaging from Visible Light Endoscopic Images

C11894: 3D Imaging Endoscope Method and SoftwareNovelty: Inventors at Hopkins have developed a safer method for determining the diameter of an airway, specifically for stenosis, the abnormal narrowing of the airway.Value Proposition: The problem of stenosis, or abnormal narrowing of the airway is an upper airway anomaly that presents frequently in children...

Published: 5/9/2024 | Inventor(s): Eric Meisner, Daniel Mirota, Masaru Ishii, Haluk Tokgozoglu, Gregory Hager

Keywords(s): Disease Indication, Gastrointestinal Disorders, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Small Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger

C11498: Effective Treatment of Acute Diarrhea Using a Novel Peptide Modification Novelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea. Value Proposition: The Center for Disease Control recommends...

Published: 5/9/2024 | Inventor(s): Randen Patterson, Damian Van Rossum, Nicholas Zachos, Mark Donowitz

Keywords(s): Acute Diarrhea, Basic Research Biomarker, Biologics, Cell Signaling, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Molecular Switches/Receptors, Peptide, Peptides, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Gastroenterology

1 2