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Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 5/9/2024 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

Radiolabeled Thapsigargin Analogs Incorporated into Protease Activated Prodrugs

Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific membrane antigen (PSMA), prostate specific antigen (PSA) or human glandular kallikrein 2 (hK2). Various embodiments relate more specifically to PSA, hK2 or PSMA-specific peptide prodrugs that become...

Published: 5/9/2024 | Inventor(s): Soren Christensen, John Isaacs, Samuel Denmeade

Keywords(s): Biologics, Cancers, Disease Indication, Peptide, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

Compositions and Method for Production of Size-Controlled Ternary Nanoparticles for Sustained Release of Peptide Therapeutics

Unmet NeedType 2 diabetes (T2D) contributes to 90% of all cases of diabetes and represents a critical global public health problem. T2D specifically affects glucose metabolism and those with the disease either do not produce enough insulin or do not respond properly to insulin signaling to maintain normal levels of glucose in the blood. Several serious...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Zhiyu He, Yizong Hu, Yongming Chen, Lixin Liu

Keywords(s): Biologics, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

B7-DC Variants in the Stimulation of Immune Responses

Unmet NeedUnfortunately, many human tumor cells have evolved ways of deactivating the body’s immune system by expressing inhibitory signals (e.g., PD-L1, CTLA-4) on tumor cell surfaces. As a consequence, there is a pressing need for novel immunotherapies that would allow immune cells to bypass specific inhibitory signals on tumor cells and carry out...

Published: 5/9/2024 | Inventor(s): Lieping Chen

Keywords(s): Bacterial Infections, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

RiBns for Rhomboid Proteases

This invention describes a method for creating novel, inhibitors of desired bacterial rhomboid proteases (RhP), and applies this method to produce potent antibiotics. The value proposition is very high providing a means of identifying and creating novel, specific bacterial Rhp inhibitors (antibiotics) with a novel mechanism of action to prevent/overcome...

Published: 5/9/2024 | Inventor(s): Sinisa Urban, Shiv Gandhi, Sangwoo Cho

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Biologics, Disease Indication, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules

P75 Neurotrophin Receptor Antagonist for the Treatment of Acute and Chronic Cardiac Disease

Unmet Need / Invention Novelty: Hemodynamic stress during heart disease results in adverse remodeling and loss of function of the myocardial tissue. One mechanism that underlies this pathology is activation of the p75 neurotrophin receptors (p75NTR) in the heart. There is an unmet need for a therapeutic which blocks the p75 neurotrophin receptor in...

Published: 5/9/2024 | Inventor(s): Nazareno Paolocci, Ning Feng, Carlo Tocchetti, Cyrus Takahashi, Bruce Carter

Keywords(s): Antagonists/Inhibitors, Biologics, Cardiovascular Diseases, Disease Indication, Myocardial Infarction (MI), Non-novel, Peptide, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular > Acute Heart Failure

Snake Toxins and their Use as Pharmacological Modulators of GABAa Receptors

Ionotropic γ-aminobutyric acid type A (GABAA) receptors are found primarily in the central nervous system (CNS) where they mediate inhibitory post-synaptic transmission by increasing CI" conductance into the cell. However, GABAA receptor activation can be excitatory in neonatal neurons and dorsal root ganglia where intracellular CI" concentrations...

Published: 5/9/2024 | Inventor(s): Pierre Bougis, Frank Bosmans

Keywords(s): Biologics, CNS and Neurological Disorders, Disease Indication, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

A novel Malaria vaccine candidate

Novel Peptide Targeting for Malaria Therapeutic ApplicationsJHU REF: C12845Invention Novelty: Use of Plasmodium-derived peptides to reduce red blood cell invasion of Plasmodium parasites for the prevention and treatment of malariaValue Proposition: Malaria is an infectious disease caused by Plasmodium parasites. In order to induce fatal symptoms of...

Published: 5/9/2024 | Inventor(s): Jurgen Bosch, Daisy Colon Lopez, Ryan Smith

Keywords(s): Biologics, Disease Indication, Immunotherapy, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Targeting Collagen Strands for Imaging and Therapy

C11749: Novel Collagen Targeting for Imaging and Therapeutic ApplicationsNovelty: This technology employs collagen mimetic peptides to target denatured collagen in vivo for imaging and treatment of cancer and other diseases affecting the collagen matrix.Value Proposition: There are currently no available means of targeting a denatured collagen matrix...

Published: 5/9/2024 | Inventor(s): Yang Li, Catherine Foss, Allen Yi-Lan Wang, Martin Pomper, Daniel Summerfield, Michael Yu

Keywords(s): Biologics, Cancers, Cardiovascular Diseases, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Peptide, Radioisotope Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Selectively Targeted Coating of Tumor Cells with Foreign Antigenic Peptide Renders Tumor Cells Susceptible to Antigen-specific CD8+ T Cell-mediated Killing

C11613: Novel Immunotherapy for Ovarian CancerNovelty: This invention is an immunotherapy that coats tumor cells with foreign antigenic peptide thereby rendering the coated tumor cells susceptible to immune recognition and elimination.Value Proposition: Cancer is the second most common cause of death in the industrialized world. Ovarian cancer is the...

Published: 5/9/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Immunotherapy, Ovarian Cancer, Peptide, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Therapeutic Modalities > Peptides

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